Clinical research group

NEFR Bruxelles Woluwe

Clinical Research

Clinical research in the Division of Nephrology of the Cliniques universitaires Saint-Luc includes 4 mains axes of research:

  • Progression, complications and treatment of autosomal dominant polycystic kidney disease, the most frequent form of inherited kidney disease;
  • Mechanisms of water transport in peritoneal dialysis;
  • Clinical nephrology, including crystal and complement-mediated kidney diseases;
  • Long-term outcome of patients after renal transplantation.

Autosomal dominant polycystic kidney disease and other inherited kidney diseases

Multicenter, open-label, extension trial to evaluate the long-term efficacy and safety of early versus delayed treatment with tolvaptan in autosomal dominant polycystic kidney disease: the TEMPO 4:4 Trial  Torres VE, Chapman AB, Devuyst O, Gansevoort RT, Perrone RD, Dandurand A, Ouyang J, Czerwiec FS, Blais JD  Nephrol Dial Transplant. 2017 Mar 31.

Urine Osmolality, Response to Tolvaptan, and Outcome in Autosomal Dominant Polycystic Kidney Disease: Results from the TEMPO 3:4 Trial  Devuyst O, Chapman AB, Gansevoort RT, Higashihara E, Perrone RD, Torres VE, Blais JD, Zhou W, Ouyang J, Czerwiec FS  J Am Soc Nephrol. 2017 May;28(5):1592-1602.

Clinical and mutational spectrum of hypoparathyroidism, deafness and renal dysplasia syndrome  Belge H, Dahan K, Cambier JF, Benoit V, Morelle J, Bloch J, Vanhille P, Pirson Y, Demoulin N  Nephrol Dial Transplant. 2017 May 1;32(5):830-837.

Paradoxical response to furosemide in uromodulin-associated kidney disease Labriola L, Olinger E, Belge H, Pirson Y, Dahan K, Devuyst O  Nephrol Dial Transplant. 2015 Feb;30(2):330-5.

Dialysis

Efficiency and safety of a Double Icodextrin dose in elderly incident CAPD patients on incremental Peritoneal Dialysis therapy: the DIDo study.  Goffin E. EudraCT: 2011-005274-30 - ClinicalTrials.gov Identifier: NCT01944852

Infectious complications following conversion to buttonhole cannulation of native arteriovenous fistulas: a quality improvement report.  Labriola L, Crott R, Desmet C, André G, Jadoul M  Am J Kidney Dis. 2011 Mar;57(3):442-8.

Clinical nephrology, including crystal nephropathies and complement-mediated kidney diseases

Enteric hyperoxaluria in chronic pancreatitis.  Demoulin N, Issa Z, Crott R, Morelle J, Danse E, Wallemacq P, Jadoul M, Deprez PH  Medicine (Baltimore). 2017 May;96(19):e6758.

Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis.  Jayne DR, Bruchfeld AN, Harper L, Schaier M, Venning MC, Hamilton P, Burst V, Grundmann F, Jadoul M, Szombati I, Tesař V, Segelmark M, Potarca A, Schall TJ, Bekker P  J Am Soc Nephrol. 2017 Apr 11. pii: ASN.2016111179.

Long-term outcome of patients after renal transplantation

Long-term Outcome of Kidney Recipients Transplanted for Aristolochic Acid Nephropathy.  Kanaan N, Hassoun Z, Raggi C, Jadoul M, Mourad M, De Meyer M, Aydin S, Schmeiser HH, Cosyns JP, Goffin E  Transplantation. 2016 Feb;100(2):416-21.

Outcome of hepatitis B and C virus-associated hepatocellular carcinoma occurring after renal transplantation  Kanaan N, Raggi C, Goffin E, De Meyer M, Mourad M, Jadoul M, Beguin C, Kabamba B, Borbath I, Pirson Y, Hassoun Z  J Viral Hepat. 2017 May;24(5):430-435.