MOTOR SKILL LEARNING AND INTENSIVE NEUROREHABILITATION LAB (MSL-IN)
RESEARCH
Our research group was developed following the creation of the Chair for neurophysiological evidences in intensive neurorehabilitation. We aim to investigate the optimal parameters of intensive rehabilitation for patients with brain damage. The measurement of this optimum is embodied both through functional assessments in the 3 areas of the ICF and through the measure of associated cortical changes with functional magnetic resonance imaging (fMRI), diffusion imaging (DTI) or transcranial magnetic stimulation (TMS).
Intensive rehabilitation: motor rehabilitation based on motor skill learning in a context of increased intensity (typically for children with cerebral palsy, 2 to 3 weeks for a total of 60 to 90 hours). In the scientific literature, most intensive interventions for children are directed to motor improvements of the upper extremities in children with unilateral impairment: Constraint Induced Movement Therapy (CIMT- unimanual) or Hand and Arm bimanual Intensive Therapy (HABIT, bimanual). Since 2011, our team has developed a new form of intensive neurorehabilitation in order to target -in the window of opportunity- both upper and lower extremities in brain-damaged patients: Hand and Arm bimanual Intensive Therapy Including Lower Extremities (HABIT-ILE).
Intensive rehabilitation and cortical plasticity: Changes induced by these intensive interventions in children's functional abilities are likely due to the cortical reorganization they elicit, the neuroplastic structure of the brain allowing to develop further some of its areas in response to the stimuli it undergoes. Different neurophysiological investigations are used in our research group to capture these cortical changes: functional magnetic resonance imaging (fMRI), diffusion imaging (DTI) and transcranial magnetic stimulation (TMS).
Target population: intensive neurorehabilitation is proposed for pathologies generated by a brain damage. Currently our research interests are focused on cerebral palsy (CP), the leading cause of pediatric motor disability in most Western countries. CP is due to an irreversible brain lesion occurring during pregnancy, at childbirth or in the first months after birth. The consequences of this type of injury are highly variable and usually include motor disorders (walking or grasping difficulties) that have important consequences on the functional abilities of these children (daily living activities such as dressing, eating, toileting ...), thereby limiting their autonomy. Currently, treatments which have shown objectively the best opportunities to improve the functional abilities of children with CP are intensive interventions.
The current projects are :
• Influence of corticospinal re-organization on plastic changes during intensive training in children with unilateral cerebral palsy
• HABIT-ILE in children with di-tri- and quadriplegia: could they benefit from motor skill learning?
• The role of visuo-spatial attention in the motor learning process of children with unilateral cerebral palsy (soutenu par JED-Belgique)
• Interlimb coordination in children with unilateral cerebral palsy
• Modifications everyday life activities and autonomy after intensive neurorehabilitation – link with cortical modifications (soutenu par le Fonds de soutien Marguerite-Marie Delacroix)
• Measuring motor learning in bimanual coordination through the Two-Arm Coordination Test
• Tactile Deficit and its Adaptability associated with Intensive Bimanual Therapy and Tactile Training in Children with Unilateral Spastic Cerebral Palsy
• Development of ACTIVLIM-CP a new Rasch-built scale for measuring global activity in children with cerebral palsy
To support our projects, you can go through Fondation Louvain, by indicating as communication « soutien rééducation intensive»
TEAM
Principal Investigators
• Yannick BLEYENHEUFT, PT, PhD (Head of the research group)
• Anne DE VOLDER, MD, PhD, Senior Research Associate FNRS.
PhD Students
- Daniela EBNER KARESTINOS, PhD Student
- Gaëtan ICKX, PhD Student
- Julie PARADIS, PhD Student
- Geoffroy SAUSSEZ, PhD Student
- Anne KLÖCKER, PhD Student
- Emmanuel SOGBOSSI, PhD Student
- Arnaud PHILIPPOT, PhD Student
Postdoctoral fellows
• Rodrigo ARANEDA, PhD
Technical and administraitive staff
• Leila AZZAZ, accountant
• Benvenuto JACOB, computer scientist
• Cécile LOMBART, industrial engineer
• Christian LEBEGUE, electronics technician
• Sébastien WILMET, computer scientist
Cathy Friand, administrative assistant
COLLABORATIONS
International
• Prof Andrew M Gordon, PhD, Center for Cerebral Palsy Research, Teachers College, Columbia University, New York, USA (http://www.tc.columbia.edu/centers/cit/index.asp?Id=Home&Info=Home)
• Dr Kathleen M Friel, PhD, Clinical Laboratory for Early Brain Injury Recovery, Burke-Cornell Medical College, New York, USA (http://www.burke.org/research/faculty/27)
• Dr Eugene Rameckers, PhD, Maastricht University, Adelante center of expertise, the Netherlands.
• Dr Sylvain Brochard, MD, PhD, CHU de Brest, Université européenne de Bretagne, France (http://www.hugoperen.org/qui-sommes-nous/comites-scientifiques/dr-sylvain-brochard/)
• Dr Marina de Brito Brandao, OT, PhD, Universidade Federale Minas Gerais, Belo Horizonte, Brazil.
• Dr Paula PLAZA, PhD, Georgetown University, Washington, USA.
National
• Dr Carlyne Arnould, PT, PhD, enseignant chercheur Haute Ecole Louvain en Hainaut.
• Prof Samar Hatem, MD, PhD, Médecine Physique et réadaptation Hôpital Brugman / Vrije Universiteit Brussels.
• Prof Jean-Louis Thonnard, PT, PhD, COSY, Institute of neuroscience, Université catholique de Louvain.
• Prof Philippe Lefèvre, Ir, PhD, ICTEAM/COSY, Université catholique de Louvain.
• Dr Anne Renders, MD and her therapeutic team, Centre IMOC, Cliniques universitaires St-Luc
• Prof. Laurent Renier, PhD, Innoviris 2010-15.
• Prof. Pierre PHILIPPOT, PhD, UCL/IPSY
• Dr Naïma DEGGOUJ, MD, PhD, ENT Dept., Cliniques Universitaires St-Luc.
• Dr Philippe ROMBAUX, MD, PhD, ORL Dept., Cliniques Universitaires St-Luc.
• Dr Yves VANDERMEEREN, MD, PhD, NEUR Dept., CHU Dinant Mont-Godinne.
• Dr Fernando BERMEJO, Visiting researcher.
• Dr Isabelle CUEVAS, PhD in 2010.