Developmental neurobiology group

 

 

        

Research

Team

Collaborations

Publications

              

Research

The laboratory of Developmental neurobiology (DENE) studies genes and proteins implicated in neural development, with a particular emphasis on planar cell polarity (PCP) genes Celsr1-3, and on Formins. Mutations in those genes have been induced in mice and their phenotypes are actively investigated using anatomical, biochemical, and cellular techniques, as well as in vitro culture systems.
Analysis of the mutant phenotypes provides clear hypotheses on the mechanisms of action of these proteins during neural development. They might at the long run help developing repair strategies for the injured and/or diseased nervous system.

The current projects are:

1. Role of PCP proteins in ependymal polarity.
2. Celsr3 in hindlimb innervation and locomotor circuitry development.
3. Role of Celsr1 in neural stem cells.
4. O-fucosylation and fringe modification of Celsr1.
5. Identification of Celsr3 and FZD3 partners.
6. Formin DIAP3 in cortical development.
7. Role of Celsr3 in the neurogenic to gliogenic switch.

Team

Principal Investigator

• Fadel TISSIR, PhD, Head of Unit

Scientific Collaborator

• André GOFFINET, MD, PhD

Postdoctorate fellows

• Eva LAU, Postdoctorate Fellow 
• Nicolas PARMENTIER, Postdoctorate Fellow
• Janne HAKANEN, Postdoctorate Fellow
• Fei WANG, Postdoctorate Fellow
• Nuria RUIZ REIG, Postdoctorate Fellow

Technical and administrative staff

• Valérie BONTE, Technician
• Rachid EL KADDOURI, Technician
• Isabelle LAMBERMONT, Technician
• Vincent SOUPART, Technician
• Esther PAITRE, Technician
• Cathy FRIAND, Administrative Assistant

Collaborations

National collaborations

• Frédéric Clotman, Philippe Gailly, UCL
• Pierre Vanderhaeghen, Serge Schiffmann, Mario Manto, Cédric Blanpain, ULB
• Brigitte Malgrange, Laurent Nguyen, ULG

International collaborations

• Yimin Zhou, La Jolla, USA
• Alessandra Piernai, Université Paris Diderot, France
• Anand Chandrasekhar, University of Missouri, USA
• Joroen Pasterkamp, University Medical Center Utrecht, The Netherlands
• Françoise Helmbacher, Aix-Marseille Université, France
• Tadashi Uemura, Kyoto University, Japan
• Sonia Garel, Ecole Normale Supérieur, France
• Mireille Montcouquiol, Neurocentre Magendie, France