Spyridon Agathos

Recherche fondamentale et appliquée dans les domaines suivants: - catalyse enzymatique et stabilisation d'enzymes - optimisation de bioprocédés pour la production de molécules d'intérêt pharmaceutique, nutrititif ou industriel à  partir de bactéries, de champignons et d'algues - conception, analyse et développement de bioréacteurs pour la production de protéines recombinantes au moyen de cellules animales - propagation et différenciation contrôlées de cellules souches en bioréacteur - biodégradation des polluants toxiques et bioremédiation - biotechnologie pour le développement durable

THESES DE DOCTORAT PROMUES

Rutgers

University

 1.       

J. Lee, Ph.D. in Chemical & Biochemical Enginering, August 1989, Physiological Factors in Cyclosporin A Production by Tolypocladium inflatum

- Experimental and Mathematical Modeling

2.      

G.-T. Chun, Ph.D. in Chemical & Biochemical Enginering, January 1992, Comparative Bioreactor Studies of Suspended and

Immobilized Cell Systems for Optimal Production of Cyclosporin A

3.        

E.K. Hong, Ph.D., January 1992, Plasmid Propagation and Heterologous Gene Expression in Recombinant Yeast (Co-supervisor: A. Constantinides)

4.        

W. Hensler, Ph.D., January 1994, Growth, Infectivity, and Recombinant Protein Expression in Insect Cell Culture

Catholic

University of Louvain

5.        

S. El Fantroussi, Doctorate in Applied Natural Sciences, May 1997, Introduction of Anaerobic Bioremediation Activities in Soil: From Laboratory Bench Scale to Pilot Soil Bioreactor (Co-supervisor: H. Naveau)

6.        

C.M. Peres, 

Doctorate in Agronomical Sciences and Bioengineering, November 1998, Improved Biodegradation of Nitroaromatic Compounds: Degradation of a Nitroaromatic Compound together with the Aminoaromatic Derivative Produced by its Reduction

7.       

V.A. Acha  Fuertes, Doctorate in Agronomical Sciences and Bioengineering, June 1999, Development of a FTIR Sensor for Monitoring and Modelling an Anaerobic Dechlorinating Bioreactor (Co-supervisor: H. Naveau)

8.        

S. Goux

, Doctorate in Agronomical Sciences and Bioengineering, March 2000, Biodegradation of Atrazine by Soil Microorganisms: Molecular Aspects and Potential Use in Bioremediation (Co-supervisor: L. Pussemier)

9.       

B. Van Aken,

Doctorate in Agronomical Sciences and Bioengineering,

November 2000, Biodegradation of 2;4;6-Trinitrotoluene (TNT) by White-Rot Fungi

10.        

L. Coulibaly, Doctorate in Agronomical Sciences and Bioengineering, 

January 2002, Bioconversion de macromolécules dans un réacteur simulant un écoulement piston en régime transitoire : cas de la bioremédiation d'eaux usées synthétiques par Aspergillus niger



11.      

L. Ikonomou, Doctorate in Applied Sciences, June 2002, Development of High Density Systems for the Production of Recombinant Proteins by Insect Cells

(Co-supervisor: G. Bastin).

12.    

J. Mols, Doctorate in Sciences, July 2004. 

Cultivation of Chinese Hamster Ovary (CHO) Cells in Protein-Free Media Supplemented with Plant Peptones is Sufficient to Prevent Proteolysis of Secreted Rcombinant Glycoproteins (Co-supervisor: Y.-J. Schneider)

13.        

J. Dries, Doctorate

in Agronomical Sciences and Bioengineering

, September 2004. 

Development and Comparison

of Different Multiple Permeable Reactive Barrier (MPRB) Concepts for the Treatment of Groundwater Contaminated by Pollutant Mixtures (

Co-supervisor:

L. Bastiaens

).

14.        

L. Eyers, Doctorate in

Agronomical Sciences and Bioengineering

, January 2007. Characterization of Bacterial Populations of 2,4,6-Trinitrotoluene (TNT) Contaminated Soils and Isolation of a Pseudomonas aeruginosa

Strain with TNT Denitration Activities.

15.         

J.-C. Drugmand, Doctorate in

Agronomical Sciences and Bioengineering

, February 2007. Characterization of Insect Cell Lines Is Required for Appropriate Industrial Processes: Case Study of High-Five Cells for Recombinant Protein Production.

16.        

L. Schuler, Doctorate in Exact Sciences, December 2007. Identification of Genes Involved in the Degradation of Polycyclic Aromatic Hydrocarbons by Two Sphingomonas

spp.

17.        

H. Cabana, Joint doctorate in Agronomical Sciences and Bioengineering (Catholic University of Louvain) and in Applied Sciences -- specialization Chemical Engineering (University of Sherbrooke, Québec, Canada), April 2008. Elimination of the endocrine disruptors nonylphenol, bisphenol A and triclosan by the oxidative action of the laccase from Coriolopsis polyzona

.

18.      

Benoît Stenuit, Doctorate in Agronomical Sciences and Bioengineering, November 2009. Biological degra

19.    Jean-François Michiels, Doctorate in Agronomical Sciences and Bioengineering, May 2011. Investigation of the role of peptones in animal cell culture: Case study of a commercial soy peptone in a CHO cell serum-free medium (Co-supervisor: Y.-J. Schneider).

20.    Sébastien Sart, Doctorate in Agronomical Sciences and Bioengineering, August 2011. Controlled expansion and differentiation of mesenchymal stem cells in microcarrier-based stirred bioreactors (Co-supervisor: Y.-J. Schneider).