Publications

Newson, Justine ; Motwani, Madhur P. ; Kendall, Alexandra C. ; Nicolaou, Anna ; Muccioli, Giulio ; Al Houayek, Mireille ; Bennett, Melanie ; Van De Merwe, Rachel ; James, Sarah ; De Maeyer, Roel P.H. ; Gilroy, Derek W.. Inflammatory Resolution Triggers a Prolonged Phase of Immune Suppression through COX-1/mPGES-1-Derived Prostaglandin E 2. In: Cell Reports, Vol. 20, no. 13, p. 3162-3175 (2017). doi:10.1016/j.celrep.2017.08.098.

http://hdl.handle.net/2078.1/193464

Al Houayek, Mireille ; Bottemanne, Pauline ; Makriyannis, Alexandros ; Muccioli, Giulio. N-acylethanolamine-hydrolyzing acid amidase and fatty acid amide hydrolase inhibition differentially affect N-acylethanolamine levels and macrophage activation. In: Biochimica et Biophysica Acta. Molecular and Cell Biology of Lipids, Vol. 1862, no. 5, p. 474-484 (2017). doi:10.1016/j.bbalip.2017.01.001.

http://hdl.handle.net/2078.1/181908

Guillemot, Owein ; Muccioli, Giulio. Obesity-Induced Neuroinflammation: Beyond the Hypothalamus. In: Trends in Neurosciences, Vol. 40, no.4, p. 237-253 (2017). doi:10.1016/j.tins.2017.02.005.

http://hdl.handle.net/2078.1/186000

Buyck, Julien ; Luyckx, C. ; Muccioli, Giulio ; Krause, K.M. ; Nichols, W. W. ; Tulkens, Paul M. ; Van Bambeke, Françoise. Pharmacodynamics of ceftazidime/avibactam against extracellular and intracellular forms of Pseudomonas aeruginosa. In: Journal of Antimicrobial Chemotherapy, Vol. 72, no.5, p. 1400-1409 (2017). doi:10.1093/jac/dkw587.

http://hdl.handle.net/2078.1/186492

Van Hee, Vincent F ; Labar, Daniel ; Dehon, Gwenaël ; Grasso, Debora ; Gregoire, Vincent ; Muccioli, Giulio ; Frédérick, Raphaël ; Sonveaux, Pierre. Radiosynthesis and validation of (±)-[18F]-3-fluoro-2-hydroxypropionate ([18F]-FLac) as a PET tracer of lactate to monitor MCT1-dependent lactate uptake in tumors. In: OncoTarget, Vol. 8, no. 15, p. 24415-24428 (2017). doi:10.18632/oncotarget.14705.

http://hdl.handle.net/2078.1/179754

Bindels, Laure B. ; Segura Munoz, Rafael R ; Gomes-Neto, João Carlos ; Mutemberezi, Valentin ; Martínez, Inés ; Salazar, Nuria ; Cody, Elizabeth A ; Quintero-Villegas, Maria I ; Kittana, Hatem ; de Los Reyes-Gavilán, Clara G ; Schmaltz, Robert J ; Muccioli, Giulio ; Walter, Jens ; Ramer-Tait, Amanda E. Resistant starch can improve insulin sensitivity independently of the gut microbiota. In: Microbiome, Vol. 5, no.1, p. 12 [1-16] (2017). doi:10.1186/s40168-017-0230-5.

http://hdl.handle.net/2078.1/182300

Valderrama, Jaime A. ; Cabrera, Mónica ; Benites, Julio ; Ríos, David ; Inostroza-Rivera, Ricardo ; Muccioli, Giulio ; Buc Calderon, Pedro. Synthetic approaches and in vitro cytotoxic evaluation of 2-acyl-3-(3,4,5-trimethoxyanilino)-1,4-naphthoquinones. In: R S C Advances : an international journal to further the chemical sciences, Vol. 7, no.40, p. 24813-24821 (2017). doi:10.1039/c7ra03238b.

http://hdl.handle.net/2078.1/185913

Beloqui Garcia, Ana ; Al Houayek, Mireille ; Carradori, Dario ; Vanvarenberg, Kevin ; Muccioli, Giulio ; Cani, Patrice D. ; Préat, Véronique. A Mechanistic Study on Nanoparticle-Mediated Glucagon-Like Peptide-1 (GLP-1) Secretion from Enteroendocrine L Cells.. In: Molecular Pharmaceutics, Vol. 13, no.12, p. 4222-4230 (2016). doi:10.1021/acs.molpharmaceut.6b00871.

http://hdl.handle.net/2078.1/178983

Beloqui Garcia, Ana ; Memvanga Bondo, Patrick ; Coco, Régis ; Reimondez-Troitiño, Sonia ; Al Houayek, Mireille ; Muccioli, Giulio ; Alonso, María José ; Csaba, Noemi ; de la Fuente, María ; Préat, Véronique. A comparative study of curcumin-loaded lipid-based nanocarriers in the treatment of inflammatory bowel disease.. In: Colloids and Surfaces B: Biointerfaces, Vol. 143, p. 327-335 (2016). doi:10.1016/j.colsurfb.2016.03.038.

http://hdl.handle.net/2078.1/174760

Ibacache, Juana Andrea ; Valderrama, Jaime A ; Arancibia, Verónica ; Theoduloz, Cristina ; Muccioli, Giulio ; Benites, Julio. Antiproliferative activity of new 6-bromine derivatives of 7-anilino-1-arylisoquinolinequinones. In: Journal of the Chilean Chemical Sociaty, Vol. 61, no. 4, p. 3191-3194 (2016). doi:10.4067/S0717-97072016000400008.

http://hdl.handle.net/2078.1/186002

Caruano, Joséphine ; Muccioli, Giulio ; Robiette, Raphaël. Biologically active γ-lactams: synthesis and natural sources. In: Organic & Biomolecular Chemistry, Vol. 14, no.43, p. 10134-10156 (2016). doi:10.1039/C6OB01349J.

http://hdl.handle.net/2078.1/178217

Guada ramirez, Melissa ; Beloqui Garcia, Ana ; Al Houayek, Mireille ; Muccioli, Giulio ; Dios-Viéitez, Maria del Carmen ; Préat, Véronique ; Blanco-Prieto, Maria J.. Cyclosporine A-loaded lipid nanoparticles in inflammatory bowel disease. In: International Journal of Pharmaceutics, Vol. 503, no. 1-2, p. 196-198 (2016). doi:10.1016/j.ijpharm.2016.03.012.

http://hdl.handle.net/2078.1/175320

Masquelier, Julien ; Muccioli, Giulio. Development and validation of a specific and sensitive HPLC-ESI-MS method for quantification of lysophosphatidylinositols and evaluation of their levels in mice tissues. In: Journal of Pharmaceutical and Biomedical Analysis, Vol. 126, no.1, p. 132-140 (2016). doi:10.1016/j.jpba.2016.04.011.

http://hdl.handle.net/2078.1/175318

Mutemberezi, Valentin ; Masquelier, Julien ; Guillemot-Legris, Owein ; Muccioli, Giulio. Development and validation of an HPLC-MS method for the simultaneous quantification of key oxysterols, endocannabinoids, and ceramides: variations in metabolic syndrome. In: Analytical and Bioanalytical Chemistry, Vol. 408, no. 3, p. 733-745 (2016). doi:10.1007/s00216-015-9150-z.

http://hdl.handle.net/2078.1/173256

Guillemot-Legris, Owein ; Masquelier, Julien ; Everard, Amandine ; Cani, Patrice D. ; Al Houayek, Mireille ; Muccioli, Giulio. High-fat diet feeding differentially affects the development of inflammation in the central nervous system. In: Journal of Neuroinflammation, Vol. 13, no.1, p. 206 [1-11] (2016). doi:10.1186/s12974-016-0666-8.

http://hdl.handle.net/2078.1/180713

Gerin, Isabelle ; Ury, Benoît ; Breloy, Isabelle ; Bouchet-Seraphin, Céline ; Bolsée, Jennifer ; Halbout, Mathias ; Graff, Julie ; Vertommen, Didier ; Muccioli, Giulio ; Seta, Nathalie ; Cuisset, Jean-Marie ; Dabaj, Ivana ; Quijano-Roy, Susana ; Grahn, Ammi ; Van Schaftingen, Emile ; Bommer, Guido. ISPD produces CDP-ribitol used by FKTN and FKRP to transfer ribitol phosphate onto α-dystroglycan. In: Nature Communications, Vol. 7, no. 1, p. 11534 [1-15] (2016). doi:10.1038/ncomms11534.

http://hdl.handle.net/2078.1/175322

Mignion, Lionel ; Danhier, Pierre ; Magat, Julie ; Porporato, Paolo ; Masquelier, Julien ; Grégoire, Vincent ; Muccioli, Giulio ; Sonveaux, Pierre ; Gallez, Bernard ; Jordan, Bénédicte. Non-invasive in vivo imaging of early metabolic tumor response to therapies targeting choline metabolism.. In: International Journal of Cancer, Vol. 138, no. 8, p. 2043-2049 (2016). doi:10.1002/ijc.29932.

http://hdl.handle.net/2078.1/167746

Guillemot-Legris, Owein ; Mutemberezi, Valentin ; Cani, Patrice D. ; Muccioli, Giulio. Obesity is associated with changes in oxysterol metabolism and levels in mice liver, hypothalamus, adipose tissue and plasma.. In: Scientific Reports, Vol. 6, p. 19694 [1-11] (2016). doi:10.1038/srep19694.

http://hdl.handle.net/2078.1/175108

Orefice, Nicola S. ; Al Houayek, Mireille ; Carotenuto, Antonio ; Montella, Silvana ; Barbato, Franscesco ; Comelli, Albert ; Calignano, Antonio ; Muccioli, Giulio ; Orefice, Giuseppe. Oral Palmitoylethanolamide Treatment Is Associated with Reduced Cutaneous Adverse Effects of Interferon-β1a and Circulating Proinflammatory Cytokines in Relapsing–Remitting Multiple Sclerosis. In: Neurotherapeutics, Vol. 13, no. 2, p. 428-438 (2016). doi:10.1007/s13311-016-0420-z.

http://hdl.handle.net/2078.1/175321

Guillemot-Legris, Owein ; Mutemberezi, Valentin ; Muccioli, Giulio. Oxysterols in Metabolic Syndrome: From Bystander Molecules to Bioactive Lipids. In: Trends in Molecular Medicine, Vol. 22, no. 7, p. 594-614 (2016). doi:10.1016/j.molmed.2016.05.006.

http://hdl.handle.net/2078.1/175314

Mutemberezi, Valentin ; Guillemot-Legris, Owein ; Muccioli, Giulio. Oxysterols: From cholesterol metabolites to key mediators. In: Progress in Lipid Research, Vol. 64, p. 152-169 (2016). doi:10.1016/j.plipres.2016.09.002.

http://hdl.handle.net/2078.1/180714

Luo, Tian ; Loira Pastoriza, Cristina ; Patil, Harshad Padmanabh ; Ucakar, Bernard ; Muccioli, Giulio ; Bosquillon, Cynthia ; Vanbever, Rita. PEGylation of paclitaxel largely improves its safety and anti-tumor efficacy following pulmonary delivery in a mouse model of lung carcinoma.. In: Journal of Controlled Release, Vol. 239, p. 62-71 (2016). doi:10.1016/j.jconrel.2016.08.008.

http://hdl.handle.net/2078.1/176904

Lepannetier, Sophie ; Zanou, Bidossessi Nadège ; Yerna, Xavier ; Emeriau, Noémie ; Dufour, Inès ; Masquelier, Julien ; Muccioli, Giulio ; Tajeddine, Nicolas ; Gailly, Philippe. Sphingosine-1-phosphate-activated TRPC1 channel controls chemotaxis of glioblastoma cells.. In: Cell Calcium, Vol. 60, no. 6, p. 373-383 (2016). doi:10.1016/j.ceca.2016.09.002.

http://hdl.handle.net/2078.1/181507

Valderrama, Jaime ; Delgado, Virginia ; Sepúlveda, Sandra ; Benites, Julio ; Theoduloz, Cristina ; Buc Calderon, Pedro ; Muccioli, Giulio. Synthesis and Cytotoxic Activity on Human Cancer Cells of Novel Isoquinolinequinone–Amino Acid Derivatives. In: Molecules : a journal of synthetic organic and natural product chemistry, Vol. 21, no. 9, p. 1199 [1-14] (2016). doi:10.3390/molecules21091199.

http://hdl.handle.net/2078.1/181915

Geurts, Lucie ; Everard, Amandine ; Van Hul, Matthias ; Essaghir, Ahmed ; Duparc, Thibaut ; Matamoros, Sébastien ; Plovier, Hubert ; Castel, Julien ; Denis, Raphael G P ; Bergiers, Marie ; Druart, Céline ; Al Houayek, Mireille ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Demoulin, Jean-Baptiste ; Luquet, Serge ; Cani, Patrice D.. Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota. In: Nature Communications, Vol. 6, p. 6495 [1-15] (2015). doi:10.1038/ncomms7495.

http://hdl.handle.net/2078.1/162016

El Bakali, Jamal ; Muccioli, Giulio ; Body-Malapel, Mathilde ; Djouina, Madjid ; Klupsch, Frédérique ; Ghinet, Alina ; Barczyk, Amélie ; Renault, Nicolas ; Chavatte, Philippe ; Desreumaux, Pierre ; Lambert, Didier ; Millet, Régis. Conformational Restriction Leading to a Selective CB2 Cannabinoid Receptor Agonist Orally Active Against Colitis. In: ACS Medicinal Chemistry Letters, Vol. 6, no.2, p. 198-203 (2015). doi:10.1021/ml500439x.

http://hdl.handle.net/2078.1/157082

Izzo, Angelo A ; Muccioli, Giulio ; Ruggieri, Michael R ; Schicho, Rudolf. Endocannabinoids and the Digestive Tract and Bladder in Health and Disease.. In: Handbook of Experimental Pharmacology, Vol. 231, p. 423-447 (2015). doi:10.1007/978-3-319-20825-1_15.

http://hdl.handle.net/2078.1/167582

Valderrama, Jaime A. ; Ríos, David ; Muccioli, Giulio ; Buc Calderon, Pedro ; Brito, Iván ; Benites, Julio. Hetero-annulation reaction between 2-acylnaphthoquinones and 2-aminobenzothiazoles. A new synthetic route to antiproliferative benzo[g]benzothiazolo[2,3-b]quinazoline-7,12-quinones. In: Tetrahedron Letters, Vol. 56, no.36, p. 5103-5105 (2015). doi:10.1016/j.tetlet.2015.07.034.

http://hdl.handle.net/2078.1/167598

Bosier, Barbara ; Doyen, Pierre ; Brolet, Amandine ; Muccioli, Giulio ; Ahmed, Eman ; Desmet, Nathalie ; Hermans, Emmanuel ; Deumens, Ronald. Inhibition of the regulator of G protein signalling RGS4 in the spinal cord decreases neuropathic hyperalgesia and restores cannabinoid CB1 receptor signalling.. In: British Journal of Pharmacology, Vol. 172, no.22, p. 5333-5346 (2015). doi:10.1111/bph.13324.

http://hdl.handle.net/2078.1/172491

Vandevelde, Nathalie ; Tulkens, Paul M. ; Muccioli, Giulio ; Van Bambeke, Françoise. Modulation of the activity of moxifloxacin and solithromycin in an in vitro pharmacodynamic model of Streptococcus pneumoniae naive and induced biofilms. In: Journal of Antimicrobial Chemotherapy, Vol. 70, no. 6, p. 1713-1726 (2015). doi:10.1093/jac/dkv032.

http://hdl.handle.net/2078.1/159375

Al Houayek, Mireille ; Bottemanne, Pauline ; Subramanian, Kumar V ; Lambert, Didier ; Makriyannis, Alexandros ; Cani, Patrice D. ; Muccioli, Giulio. N-Acylethanolamine-hydrolyzing acid amidase inhibition increases colon N-palmitoylethanolamine levels and counteracts murine colitis. In: The FASEB Journal, Vol. 29, no.2, p. 650-661 (2015). doi:10.1096/fj.14-255208.

http://hdl.handle.net/2078.1/157086

Bindels, Laure B. ; Neyrinck, Audrey M. (co-first author) ; Salazar Garzo, Nuria ; Taminiau, Bernard ; Druart, Céline ; Muccioli, Giulio ; François, Emmanuelle ; Blecker, Christophe ; Richel, Aurore ; Daube, Georges ; Mahillon, Jacques ; de Los Reyes-Gavilán, Clara G ; Cani, Patrice D. ; Delzenne, Nathalie M.. Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice. In: PLoS One, Vol. 10, no. 6, p. e0131009 [1-16] (2015). doi:10.1371/journal.pone.0131009.

http://hdl.handle.net/2078.1/162011

Caruano, Joséphine ; Feledziak, Marion ; Labar, Geoffray ; Michaux, Catherine ; Perpete, Eric ; Muccioli, Giulio ; Robiette, Raphaël ; Marchand-Brynaert, Jacqueline. (S)-1-(Pent-4’-enoyl)-4-(hydroxymethyl)-azetidin-2-one derivatives as inhibitors of human fatty acid amide hydrolase (hFAAH): synthesis, biological evaluation and molecular modelling. In: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol. 29, no. /, p. 654-662 (2014). doi:10.3109/14756366.2013.837900.

http://hdl.handle.net/2078.1/137070

Al Houayek, Mireille ; Muccioli, Giulio. COX-2-derived endocannabinoid metabolites as novel inflammatory mediators. In: Trends in Pharmacological Sciences, Vol. 35, no.6, p. 284-292 (2014). doi:10.1016/j.tips.2014.03.001.

http://hdl.handle.net/2078.1/145133

Al Houayek, Mireille ; Masquelier, Julien ; Muccioli, Giulio. Controlling 2-arachidonoylglycerol metabolism as an anti-inflammatory strategy. In: Drug Discovery Today, Vol. 19, no. 3, p. 295-304 (2014). doi:10.1016/j.drudis.2013.07.009.

http://hdl.handle.net/2078.1/141045

Reychler, Gregory ; Aubriot, Anne-Sophie ; Masquelier, Julien ; Muccioli, Giulio ; Liistro, Giuseppe. Effect of drug-targeting nebulization on lung delivery. In: Archivos de Bronconeumologia, Vol. 50, no. 3, p. 500-501 (2014). doi:10.1016/j.arbres.2013.10.014.

http://hdl.handle.net/2078.1/141050

Al Houayek, Mireille ; Muccioli, Giulio. Harnessing the anti-inflammatory potential of palmitoylethanolamide.. In: Drug discovery today, , no.1-8 (2014). doi:10.1016/j.drudis.2014.06.007 (Accepté/Sous presse).

http://hdl.handle.net/2078.1/145135

Everard, Amandine ; Geurts, Lucie ; Caesar, Robert ; Van Hul, Matthias ; Matamoros, Sébastien ; Duparc, Thibaut ; Denis, Raphael G P ; Cochez, Perrine ; Pierard, Florian ; Castel, Julien ; Bindels, Laure B. ; Plovier, Hubert ; Robine, Sylvie ; Muccioli, Giulio ; Renauld, Jean-Christophe ; Dumoutier, Laure ; Delzenne, Nathalie M. ; Luquet, Serge ; Bäckhed, Fredrik ; Cani, Patrice D.. Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status. In: Nature Communications, Vol. 5, no. 1, p. 5648 [1-12] (2014). doi:10.1038/ncomms6648.

http://hdl.handle.net/2078.1/156590

Ibacache, Juana Andrea ; Delgado, Virginia ; Benites, Julio ; Theoduloz, Cristina ; Arancibia, Verónica ; Muccioli, Giulio ; Valderrama, Jaime A. Synthesis, half-wave potentials and antiproliferative activity of 1-aryl-substituted aminoisoquinolinequinones.. In: Molecules (Basel, Switzerland), Vol. 19, no.1, p. 726-39 (2014). doi:10.3390/molecules19010726.

http://hdl.handle.net/2078.1/141047

Tourteau, Aurélien ; Andrzejak, Virginie ; Body-Malapel, Mathilde ; Lemaire, Lucas ; Lemoine, Amélie ; Mansouri, Roxane ; Djouina, Madjid ; Renault, Nicolas ; El Bakali, Jamal ; Desreumaux, Pierre ; Muccioli, Giulio ; Lambert, Didier M ; Chavatte, Philippe ; Rigo, Benoît ; Leleu-Chavain, Natascha ; Millet, Régis. 3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis.. In: Bioorganic & medicinal chemistry, Vol. 21, no. 17, p. 5383-94 (2013). doi:10.1016/j.bmc.2013.06.010.

http://hdl.handle.net/2078.1/141051

Beloqui Garcia, Ana ; Coco, Régis ; Al Houayek, Mireille ; Solinís, María Ángeles ; Rodríguez-Gascón, Alicia ; Muccioli, Giulio ; Préat, Véronique. Budesonide-loaded nanostructured lipid carriers reduce inflammation in murine DSS-induced colitis. In: International Journal of Pharmaceutics, Vol. 454, no. 2, p. 775-783 (2013). doi:10.1016/j.ijpharm.2013.05.017.

http://hdl.handle.net/2078.1/131923

Geurts, Lucie ; Muccioli, Giulio ; Delzenne, Nathalie M. ; Cani, Patrice D.. Chronic endocannabinoid system stimulation induces muscle macrophage and lipid accumulation in type 2 diabetic mice independently of metabolic endotoxaemia. In: PLoS One, Vol. 8, no.2, p. e55963 [1-10] (2013). doi:10.1371/journal.pone.0055963.

http://hdl.handle.net/2078.1/131551

Everard, Amandine ; Belzer, Clara ; Geurts, Lucie ; Ouwerkerk, Janneke P ; Druart, Céline ; Bindels, Laure B. ; Guiot, Yves ; Derrien, Muriel ; Muccioli, Giulio ; Delzenne, Nathalie M. ; de Vos, Willem M ; Cani, Patrice D.. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. In: Proceedings of the National academy of sciences of the United States of America, Vol. 110, no.22, p. 9066-9071 (2013). doi:10.1073/pnas.1219451110.

http://hdl.handle.net/2078.1/131542

Arenas, Paola ; Peña, Andrés ; Ríos, David ; Benites, Julio ; Muccioli, Giulio ; Buc Calderon, Pedro ; Valderrama, Jaime A. Eco-friendly synthesis and antiproliferative evaluation of some oxygen substituted diaryl ketones. In: Molecules, Vol. 18, no. 8, p. 9818-9832 (2013). doi:10.3390/molecules18089818.

http://hdl.handle.net/2078.1/145225

Al Houayek, Mireille ; Masquelier, Julien ; Cani, Patrice D. ; Lambert, Didier M. ; Muccioli, Giulio. Implication of the anti-inflammatory bioactive lipid prostaglandin D2-glycerol ester in the control of macrophage activation and inflammation by ABHD6. In: Proceedings of the National academy of sciences of the United States of America, Vol. 110, no.43, p. 17558-17563 (2013). doi:10.1073/pnas.1314017110.

http://hdl.handle.net/2078.1/134706

Bosier, Barbara ; Muccioli, Giulio ; Lambert, Didier. The FAAH inhibitor URB597 efficiently reduces tyrosine hydroxylase expression through CB(1) and FAAH-independent mechanisms. In: British Journal of Pharmacology, Vol. 169, no. 4, p. 794-807 (2013). doi:10.1111/j.1476-5381.2012.02208.x.

http://hdl.handle.net/2078.1/119601

El Bakali, Jamal ; Gilleron, Pauline ; Body-Malapel, Mathilde ; Mansouri, Roxane ; Muccioli, Giulio ; Djouina, Madjid ; Barczyk, Amélie ; Klupsch, Frédérique ; Andrzejak, Virginie ; Lipka, Emmanuelle ; Furman, Christophe ; Lambert, Didier ; Chavatte, Philippe ; Desreumaux, Pierre ; Millet, Régis. 4-Oxo-1,4-dihydropyridines as selective CB₂ cannabinoid receptor ligands. Part 2: discovery of new agonists endowed with protective effect against experimental colitis. In: Journal of Medicinal Chemistry, Vol. 55, no. 20, p. 8948-8952 (2012). doi:10.1021/jm3008568.

http://hdl.handle.net/2078.1/141066

Bosier, Barbara ; Muccioli, Giulio ; Mertens, Birgit ; Sarre, Sophie ; Michotte, Yvette ; Lambert, Didier M ; Hermans, Emmanuel. Differential modulations of striatal tyrosine hydroxylase and dopamine metabolism by cannabinoid agonists as evidence for functional selectivity in vivo.. In: Neuropharmacology, Vol. 62, no. 7, p. 2328-2336 (2012). doi:10.1016/j.neuropharm.2012.02.003.

http://hdl.handle.net/2078.1/119604

Matuszak, Nicolas ; Hamtiaux, Laurie ; Baldeyroux, Brigitte ; Muccioli, Giulio ; Poupaert, Jacques H ; Lansiaux, Amélie ; Lambert, Didier M. Dual inhibition of MAGL and type II topoisomerase by N-phenylmaleimides as a potential strategy to reduce neuroblastoma cell growth.. In: European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, Vol. 45, no. 3, p. 263-71 (2012). doi:10.1016/j.ejps.2011.11.011.

http://hdl.handle.net/2078.1/141071

Bindels, Laure B. ; Porporato, Paolo ; Dewulf, Evelyne ; Verrax, Julien ; Neyrinck, Audrey M. ; Martin, J C ; Scott, K P ; Buc Calderon, Pedro ; Feron, Olivier ; Muccioli, Giulio ; Sonveaux, Pierre ; Cani, Patrice D. ; Delzenne, Nathalie M.. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. In: The British journal of cancer, Vol. 107, no. 8, p. 1337-1344 (2012). doi:10.1038/bjc.2012.409.

http://hdl.handle.net/2078.1/118969

Feledziak, Marion ; Lambert, Didier, M. ; Marchand-Brynaert, Jacqueline ; Muccioli, Giulio. Inhibitors of the Endocannabinoid-Degrading Enzymes, or how to Increase Endocannabinoid's Activity by Preventing their Hydrolysis. In: Recent Patents on C N S Drug Discovery, Vol. 7, no.1, p. 49-70 (2012). doi:10.2174/157488912798842223.

http://hdl.handle.net/2078.1/125508

Kapanda, Coco N ; Masquelier, Julien ; Labar, Geoffray ; Muccioli, Giulio ; Poupaert, Jacques H ; Lambert, Didier M. Synthesis and pharmacological evaluation of 2,4-dinitroaryldithiocarbamate derivatives as novel monoacylglycerol lipase inhibitors.. In: Journal of medicinal chemistry, Vol. 55, no. 12, p. 5774-83 (2012). doi:10.1021/jm3006004.

http://hdl.handle.net/2078.1/141068

Hamtiaux, Laurie ; Masquelier, Julien ; Muccioli, Giulio ; Bouzin, Caroline ; Feron, Olivier ; Gallez, Bernard ; Lambert, Didier. The association of N-palmitoylethanolamine with the FAAH inhibitor URB597 impairs melanoma growth through a supra-additive action. In: BMC Cancer, Vol. 12, p. 92 [1-12] (2012). doi:10.1186/1471-2407-12-92.

http://hdl.handle.net/2078/119829

Al Houayek, Mireille ; Muccioli, Giulio. The endocannabinoid system in inflammatory bowel diseases: from pathophysiology to therapeutic opportunity. In: Trends in Molecular Medicine, Vol. 18, no. 10, p. 615-625 (2012). doi:10.1016/j.molmed.2012.07.009.

http://hdl.handle.net/2078.1/141217

Geurts, Lucie ; Lazarevic, Vladimir ; Derrien, Muriel ; Everard, Amandine ; Van Roye, Marie ; Knauf, Claude ; Valet, Philippe ; Girard, Myriam ; Muccioli, Giulio ; François, Patrice ; de Vos, Willem M. ; Schrenzel, Jacques ; Delzenne, Nathalie M. ; Cani, Patrice D.. Altered gut microbiota and endocannabinoid system tone in obese and diabetic leptin-resistant mice : impact on apelin regulation in adipose tissue.. In: Frontiers in Microbiology, Vol. 2, p. [1-17] (2011). doi:10.3389/fmicb.2011.00149.

http://hdl.handle.net/2078.1/104558

Marrs, William R. ; Horne, Eric A. ; Ortega-Gutierrez, Silvia ; Cisneros, Jose Antonio ; Xu, Cong ; Lin, Yi Hsing ; Muccioli, Giulio ; Lopez-Rodriguez, Maria L. ; Stella, Nephi. Dual inhibition of alpha/beta-hydrolase domain 6 and fatty acid amide hydrolase increases endocannabinoid levels in neurons. In: Journal of Biological Chemistry, Vol. 286, no. 33, p. 28723-8 (2011). doi:10.1074/jbc.M110.202853.

http://hdl.handle.net/2078.1/105983

Pachikian, Barbara D. ; Essaghir, Ahmed ; Demoulin, Jean-Baptiste ; Neyrinck, Audrey M. ; Catry, Emilie ; De Backer, Fabienne ; Dejeans, Nicolas ; Dewulf, Evelyne ; Sohet, Florence ; Portois, Laurence ; Deldicque, Louise ; Molendi-Coste, Olivier ; Leclercq, Isabelle ; Francaux, Marc ; Carpentier, Yvon A ; Foufelle, Fabienne ; Muccioli, Giulio ; Cani, Patrice D. ; Delzenne, Nathalie M.. Hepatic n-3 polyunsaturated fatty acid depletion promotes steatosis and insulin resistance in mice : genomic analysis of cellular targets.. In: PLoS One, Vol. 6, no. 8, p. e23365 (2011). doi:10.1371/journal.pone.0023365.

http://hdl.handle.net/2078.1/95891

Hamtiaux, Laurie ; Hansoulle, Laurie ; Dauguet, Nicolas ; Muccioli, Giulio ; Gallez, Bernard ; Lambert, Didier. Increasing antiproliferative properties of endocannabinoids in N1E-115 neuroblastoma cells through inhibition of their metabolism. In: PLoS One, Vol. 6, no. 10, p. [1-14] (2011). doi:10.1371/journal.pone.0026823.

http://hdl.handle.net/2078.1/105968

Al Houayek, Mireille ; Lambert, Didier ; Delzenne, Nathalie M. ; Cani, Patrice D. ; Muccioli, Giulio. Increasing endogenous 2-arachidonoylglycerol levels counteracts colitis and related systemic inflammation. In: The FASEB Journal, Vol. 25, no. 8, p. 2711-2721 (2011). doi:10.1096/fj.10-176602.

http://hdl.handle.net/2078.1/104024

Dewulf, Evelyne ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Possemiers, Sam ; Van Holle, Ann ; Muccioli, Giulio ; Deldicque, Louise ; Bindels, Laure B. ; Pachikian, Barbara D. ; Sohet, Florence ; Mignolet, Eric ; Francaux, Marc ; Larondelle, Yvan ; Delzenne, Nathalie M.. Inulin-type fructans with prebiotic properties counteract GPR43 overexpression and PPARγ-related adipogenesis in the white adipose tissue of high-fat diet-fed mice.. In: The Journal of Nutritional Biochemistry, Vol. 22, no. 8, p. 712-722 (2011). doi:10.1016/j.jnutbio.2010.05.009.

http://hdl.handle.net/2078.1/68589

Duparc, Thibaut ; Naslain, Damien ; Colom, André ; Muccioli, Giulio ; Massaly, Nicolas ; Delzenne, Nathalie M. ; Valet, Philippe ; Cani, Patrice D. ; Knauf, Claude. Jejunum inflammation in obese and diabetic mice impairs enteric glucose detection and modifies nitric oxide release in the hypothalamus.. In: Antioxidants & Redox Signaling, Vol. 14, no. 3, p. 415-423 (2011). doi:10.1089/ars.2010.3330.

http://hdl.handle.net/2078.1/104258

Thabuis, Clémentine ; Destaillats, Frédéric ; Lambert, Didier ; Muccioli, Giulio ; Maillot, Matthieu ; Harach, Touafiq ; Tissot-Favre, Delphine ; Martin, Jean-Charles. Lipid transport function is the main target of oral oleoylethanolamide to reduce adiposity in high-fat-fed mice. In: Journal of Lipid Research, Vol. 52, no. 7, p. 1373-82 (2011). doi:10.1194/jlr.M013391.

http://hdl.handle.net/2078.1/106001

Sexton, Michelle ; Woodruff, Grace ; Horne, Eric A. ; Lin, Yi Hsing ; Muccioli, Giulio ; Bai, Mingfeng ; Stern, Eric ; Bornhop, Darryl J. ; Stella, Nephi. NIR-mbc94, a fluorescent ligand that binds to endogenous CB(2) receptors and is amenable to high-throughput screening. In: Chemistry & Biology, Vol. 18, no. 5, p. 563-568 (2011). doi:10.1016/j.chembiol.2011.02.016.

http://hdl.handle.net/2078.1/105997

Andrzejak, Virginie ; Muccioli, Giulio ; Body-Malapel, Mathilde ; El Bakali, Jamal ; Djouina, Madjid ; Renault, Nicolas ; Chavatte, Philippe ; Desreumaux, Pierre ; Lambert, Didier ; Millet, Régis. New FAAH inhibitors based on 3-carboxamido-5-aryl-isoxazole scaffold that protect against experimental colitis. In: Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 19, no. 12, p. 3777-3786 (2011). doi:10.1016/j.bmc.2011.04.057.

http://hdl.handle.net/2078.1/105699

Everard, Amandine ; Lazarevic, Vladimir ; Derrien, Muriel ; Girard, Myriam ; Muccioli, Giulio ; Neyrinck, Audrey M. ; Possemiers, Sam ; Van Holle, Ann ; François, Patrice ; de Vos, Willem M ; Delzenne, Nathalie M. ; Schrenzel, Jacques ; Cani, Patrice D.. Responses of gut microbiota and glucose and lipid metabolism to prebiotics in genetic obese and diet-induced leptin-resistant mice. In: Diabetes, Vol. 60, no. 11, p. 2775-2786 (2011). doi:10.2337/db11-0227.

http://hdl.handle.net/2078.1/104554

Feledziak, Marion ; Muccioli, Giulio ; Lambert, Didier ; Marchand-Brynaert, Jacqueline. SAR and LC/MS studies of β-lactamic inhibitors of human fatty acid amide hydrolase (hFAAH) : evidence of a nonhydrolytic process. In: Journal of Medicinal Chemistry, Vol. 54, no. 19, p. 6812-6823 (2011). doi:10.1021/jm200723m.

http://hdl.handle.net/2078.1/105950

Evens, Nele ; Vandeputte, Caroline ; Muccioli, Giulio ; Lambert, Didier ; Baekelandt, Veerle ; Verbruggen, Alfons M. ; Debyser, Zeger ; Van Laere, Koen ; Bormans, Guy M.. Synthesis, in vitro and in vivo evaluation of fluorine-18 labelled FE-GW405833 as a PET tracer for type 2 cannabinoid receptor imaging. In: Bioorganic & Medicinal Chemistry : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 19, no. 15, p. 4499-4505 (2011). doi:10.1016/j.bmc.2011.06.033.

http://hdl.handle.net/2078.1/105757

El Bakali, Jamal ; Muccioli, Giulio ; Renault, Nicolas ; Pradal, Delphine ; Body-Malapel, Mathilde ; Djouina, Madjid ; Hamtiaux, Laurie ; Andrzejak, Virginie ; Desreumaux, Pierre ; Chavatte, Philippe ; Lambert, Didier ; Millet, Régis. 4-Oxo-1,4-dihydropyridines as selective CB2 cannabinoid receptor ligands : structural insights into the design of a novel inverse agonist series.. In: Journal of Medicinal Chemistry, Vol. 53, no. 22, p. 7918-7931 (2010). doi:10.1021/jm100286k.

http://hdl.handle.net/2078.1/106428

De Wael, Frédéric ; Muccioli, Giulio ; Lambert, Didier ; Sergent, Thérèse ; Schneider, Yves-Jacques ; Rees, Jean-François ; Marchand-Brynaert, Jacqueline. Chemistry around imidazopyrazine and ibuprofen : discovery of novel fatty acid amide hydrolase (FAAH) inhibitors. In: European Journal of Medicinal Chemistry, Vol. 45, no. 9, p. 3564-3574 (2010). doi:10.1016/j.ejmech.2010.04.040.

http://hdl.handle.net/2078.1/32578

Muccioli, Giulio. Endocannabinoid biosynthesis and inactivation, from simple to complex.. In: Drug Discovery Today, Vol. 15, no. 11-12, p. 474-483 (2010). doi:10.1016/j.drudis.2010.03.007.

http://hdl.handle.net/2078.1/30702

Bosier, Barbara ; Muccioli, Giulio ; Hermans, Emmanuel ; Lambert, Didier. Functionally selective cannabinoid receptor signalling : therapeutic implications and opportunities. In: Biochemical Pharmacology, Vol. 80, no. 1, p. 1-12 (2010). doi:10.1016/j.bcp.2010.02.013.

http://hdl.handle.net/2078.1/33886

Collard, François ; Stroobant, Vincent ; Lamosa, Pedro ; Kapanda Nankwa, Coco ; Lambert, Didier ; Muccioli, Giulio ; Poupaert, Jacques ; Opperdoes, Frederik ; Van Schaftingen, Emile. Molecular identification of N-acetylaspartylglutamate synthase and beta-citrylglutamate synthase.. In: Journal of Biological Chemistry, Vol. 285, no. 39, p. 29826-29833 (2010). doi:10.1074/jbc.M110.152629.

http://hdl.handle.net/2078.1/33133

Wyffels, Leonie ; Muccioli, Giulio ; Kapanda Nankwa, Coco ; Labar, Geoffray ; De Bruyne, Sylvie ; De Vos, Filip ; Lambert, Didier. PET imaging of fatty acid amide hydrolase in the brain : synthesis and biological evaluation of an C-11-labelled URB597 analogue. In: Nuclear Medicine and Biology, Vol. 37, no. 5, p. 665-75 (2010). doi:10.1016/j.nucmedbio.2010.03.009.

http://hdl.handle.net/2078.1/33726

Muccioli, Giulio ; Naslain, Damien ; Bäckhed, Fredrik ; Reigstad, Christopher S. ; Lambert, Didier ; Delzenne, Nathalie M. ; Cani, Patrice D.. The endocannabinoid system links gut microbiota to adipogenesis. In: Molecular Systems Biology, Vol. 6, p. 392 [1-15] (2010). doi:10.1038/msb.2010.46.

http://hdl.handle.net/2078.1/33126

Marrs, William R. ; Blankman, Jacqueline L. ; Horne, Eric A. ; Thomazeau, Aurore ; Lin, Yi Hsing ; Coy, Jonathan ; Bodor, Agnes L. ; Muccioli, Giulio ; Hu, Sherry Shu-Jung ; Woodruff, Grace ; Fung, Susan ; Lafourcade, Mathieu ; Alexander, Jessica P. ; Long, Jonathan Z. ; Li, Weiwei ; Xu, Cong ; Moeller, Thomas ; Mackie, Ken ; Manzoni, Olivier J. ; Cravatt, Benjamin F. ; Stella, Nephi. The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors. In: Nature Neuroscience, Vol. 13, no. 8, p. 951-7 (2010). doi:10.1038/nn.2601.

http://hdl.handle.net/2078.1/33628

Feledziak, Marion ; Michaux, Catherine ; Urbach, Allan ; Labar, Geoffray ; Muccioli, Giulio ; Lambert, Didier ; Marchand-Brynaert, Jacqueline. Beta-lactams derived from a carbapenem chiron are selective inhibitors of human fatty acid amide hydrolase versus human monoacylglycerol lipase. In: Journal of Medicinal Chemistry, Vol. 52, no. 22, p. 7054-7068 (2009). doi:10.1021/jm9008532.

http://hdl.handle.net/2078.1/28546

Kapanda, Coco N. ; Muccioli, Giulio ; Labar, Geoffray ; Poupaert, Jacques ; Lambert, Didier. Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors. In: Journal of Medicinal Chemistry, Vol. 52, no. 22, p. 7310-7314 (2009). doi:10.1021/jm901323s.

http://hdl.handle.net/2078.1/28544

Cani, Patrice D. ; Possemiers, S. ; Van de Wiele, T. ; Guiot, Yves ; Everard, Amandine ; Rottier, O. ; Geurts, Lucie ; Naslain, Damien ; Neyrinck, Audrey M. ; Lambert, Didier ; Muccioli, Giulio ; Delzenne, Nathalie M.. Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. In: Gut, Vol. 58, no. 8, p. 1091-1103 (2009). doi:10.1136/gut.2008.165886.

http://hdl.handle.net/2078.1/27380

Muccioli, Giulio ; Sia, Angela ; Muchowski, Paul J. ; Stella, Nephi. Genetic manipulation of palmitoylethanolamide production and inactivation in Saccharomyces cerevisiae.. In: PLoS One, Vol. 4, no. 6, p. e5942 (2009). doi:10.1371/journal.pone.0005942.

http://hdl.handle.net/2078.1/106608

Kapanda Nankwa, Coco ; Muccioli, Giulio ; Labar, Geoffray ; Draoui, Nihed ; Lambert, Didier ; Poupaert, Jacques. Search for monoglyceride lipase inhibitors : synthesis and screening of arylthioamides derivatives. In: Medicinal Chemistry Research, Vol. 18, no. 4, p. 243-254 (2009). doi:10.1007/s00044-008-9123-2.

http://hdl.handle.net/2078.1/35613

Evens, Nele ; Muccioli, Giulio ; Houbrechts, Nele ; Lambert, Didier ; Verbruggen, Alfons M. ; Van Laere, Koen ; Bormans, Guy M.. Synthesis and biological evaluation of carbon-11-and fluorine-18-labeled 2-oxoquinoline derivatives for type 2 cannabinoid receptor positron emission tomography imaging. In: Nuclear Medicine and Biology, Vol. 36, no. 4, p. 455-465 (2009). doi:10.1016/j.nucmedbio.2009.01.009.

http://hdl.handle.net/2078.1/35555

Matuszak, Nicolas ; Muccioli, Giulio ; Labar, Geoffray ; Lambert, Didier. Synthesis and in vitro evaluation of N-substituted maleimide derivatives as selective monoglyceride lipase inhibitors. In: Journal of Medicinal Chemistry, Vol. 52, no. 23, p. 7410-7420 (2009). doi:10.1021/jm900461w.

http://hdl.handle.net/2078.1/22828

Wyffels, Leonie ; Muccioli, Giulio ; De Bruyne, Sylvie ; Moerman, Lieselotte ; Sambre, Johan ; Lambert, Didier ; De Vos, Filip. Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain. In: Journal of Medicinal Chemistry, Vol. 52, no. 15, p. 4613-4622 (2009). doi:10.1021/jm900324e.

http://hdl.handle.net/2078.1/35421

Urbach, Allan ; Muccioli, Giulio ; Stern, Eric ; Lambert, Didier ; Marchand-Brynaert, Jacqueline. 3-Alkenyl-2-azetidinones as fatty acid amide hydrolase inhibitors.. In: Bioorganic & Medicinal Chemistry Letters, Vol. 18, no. 14, p. 4163-4167 (2008). doi:10.1016/j.bmcl.2008.05.081.

http://hdl.handle.net/2078.1/12696

Muccioli, Giulio ; Stella, Nephi. An optimized GC-MS method detects nanomolar amounts of anandamide in mouse brain. In: Analytical Biochemistry, Vol. 373, no.2, p. 220-228 (2008). doi:10.1016/j.ab.2007.09.030.

http://hdl.handle.net/2078.1/157083

Muccioli, Giulio ; Labar, Geoffray ; Lambert, Didier. CAY10499, a novel monoglyceride lipase inhibitor evidenced by an expeditious MGL assay. In: ChemBioChem : a European journal of chemical biology, Vol. 9, no. 16, p. 2704-2710 (2008). doi:10.1002/cbic.200800428.

http://hdl.handle.net/2078.1/19641

Gallienne, Estelle ; Muccioli, Giulio ; Lambert, Didier ; Shipman, Michael. Microwave-assisted four-component reaction for the synthesis of a monothiohydantoin inhibitor of a fatty acid amide hydrolase. In: Tetrahedron Letters, Vol. 49, no. 46, p. 6495-6497 (2008). doi:10.1016/j.tetlet.2008.08.100.

http://hdl.handle.net/2078.1/37107

Hoet, Sara ; Pieters, Luc ; Muccioli, Giulio ; Habib Jiwan, Jean-Louis ; Opperdoes, Frederik ; Quetin-Leclercq, Joëlle. Antitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.. In: Journal of Natural Products, Vol. 70, no. 8, p. 1360-1363 (2007). doi:10.1021/np070038q.

http://hdl.handle.net/2078.1/11035

Muccioli, Giulio. Blocking the cannabinoid receptors: Drug candidates and therapeutic promises. In: Chemistry & Biodiversity, Vol. 4, no. 8, p. 1805-1827 (2007). doi:10.1002/cbdv.200790153.

http://hdl.handle.net/2078.1/37358

Labar, Geoffray ; Bauvois, Cedric ; Muccioli, Giulio ; Wouters, Johan ; Lambert, Didier. Disulfiram is an inhibitor of human purified monoacylglycerol lipase, the enzyme regulating 2-arachidonoylglycerol signaling. In: ChemBioChem, Vol. 8, no. 11, p. 1293-1297 (2007). doi:10.1002/cbic.200700139.

http://hdl.handle.net/2078.1/11009

Lambert, Didier ; Muccioli, Giulio. Endocannabinoids and related N-acylethanolamines in the control of appetite and energy metabolism: emergence of new molecular players.. In: Current opinion in clinical nutrition and metabolic care, Vol. 10, no. 6, p. 735-744 (2007). doi:10.1097/MCO.0b013e3282f00061.

http://hdl.handle.net/2078.1/11229

Muccioli, Giulio ; Xu, Cong ; Odah, Emma ; Cudaback, Eiron ; Antonio Cisneros, Jose ; Lambert, Didier ; Lopez Rodriguez, Maria Luz ; Bajjalieh, Sandra ; Stella, Nephi. Identification of a novel endocannabinoid-hydrolyzing enzyme expressed by microglial cells. In: The Journal of Neuroscience, Vol. 27, no. 11, p. 2883-9 (2007). doi:10.1523/JNEUROSCI.4830-06.2007.

http://hdl.handle.net/2078.1/37698

Stern, Eric ; Muccioli, Giulio ; Bosier, Barbara ; Hamtiaux, Laurie ; Millet, Regis ; Poupaert, Jacques ; Henichart, Jean-Pierre ; Depreux, Patrick ; Goossens, Jean-Francois ; Lambert, Didier. Pharmacomodulations around the 4-oxo-1,4-dihydroquinoline-3-carboxamides, a class of potent CB2-selective cannabinoid receptor ligands: Consequences in receptor affinity and functionality. In: Journal of Medicinal Chemistry, Vol. 50, no. 22, p. 5471-84 (2007). doi:10.1021/jm070387h.

http://hdl.handle.net/2078.1/37270

Philip, Ashok E. ; Poupaert, Jacques ; Cheve, Gwenael ; Muccioli, Giulio ; Lambert, Didier ; McCurdy, Christopher R.. Structure-activity relationship of phenytoinergic antiepileptic drugs related to ameltolide. In: Medicinal Chemistry Research : an international journal for rapid communications on design and mechanisms of action of biologically active agents, Vol. 16, no. 3, p. 130-135 (2007). doi:10.1007/s00044-007-9016-9.

http://hdl.handle.net/2078.1/36853

Michaux, Catherine ; Muccioli, Giulio ; Lambert, Didier ; Wouters, Johan. Binding mode of new (thio)hydantoin inhibitors of fatty acid amide hydrolase: comparison with two original compounds, OL-92 and JP104. In: Bioorganic & Medicinal Chemistry Letters : the tetrahedron journal for research at the interface of chemistry and biology, Vol. 16, no. 18, p. 4772-4776 (2006). doi:10.1016/j.bmcl.2006.06.087.

http://hdl.handle.net/2078.1/141075

Muccioli, Giulio ; Lambert, Didier. Latest advances in cannabinoid receptor antagonists and inverse agonists. In: Expert Opinion on Therapeutic Patents, Vol. 16, no. 10, p. 1405-1423 (2006). doi:10.1517/13543776.16.10.1405.

http://hdl.handle.net/2078.1/38222

Stern, Eric ; Muccioli, Giulio ; Millet, R ; Goossens, JF ; Farce, A ; Chavatte, P ; Poupaert, Jacques ; Lambert, Didier ; Depreux, P. ; Hénichart, Jean-Pierre. Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: Synthesis, pharmacological properties and molecular modeling. In: Journal of Medicinal Chemistry, Vol. 49, no. 1, p. 70-79 (2006). doi:10.1021/jm050467q.

http://hdl.handle.net/2078.1/38710

Muccioli, Giulio ; Fazio, Nicola ; Scriba, Gerhard K E ; Poppitz, Wolfgang ; Cannata, Fabio ; Poupaert, Jacques ; Wouters, Johan ; Lambert, Didier. Substituted 2-thioxoimidazolidin-4-ones and imidazolidine-2,4-diones as fatty acid amide hydrolase inhibitors templates.. In: Journal of Medicinal Chemistry, Vol. 49, no. 1, p. 417-425 (2006). doi:10.1021/jm050977k.

http://hdl.handle.net/2078.1/10442

Muccioli, Giulio ; Wouters, Johan ; Charlier, Caroline ; Scriba, Gerhard K E ; Pizza, Teresa ; Di Pace, Pierluigi ; De Martino, Paolo ; Poppitz, Wolfgang ; Poupaert, Jacques ; Lambert, Didier. Synthesis and activity of 1,3,5-triphenylimidazolidine-2,4-diones and 1,3,5-triphenyl-2-thioxoimidazolidin-4-ones: characterization of new CB1 cannabinoid receptor inverse agonists/antagonists.. In: Journal of medicinal chemistry, Vol. 49, no. 3, p. 872-82 (2006). doi:10.1021/jm050484f.

http://hdl.handle.net/2078.1/10469

Muccioli, Giulio ; Wouters, Johan ; Scriba, Gerhard K E ; Poppitz, Wolfgang ; Poupaert, Jacques ; Lambert, Didier. 1-Benzhydryl-3-phenylurea and 1-benzhydryl-3-phenylthiourea derivatives: new templates among the CB1 cannabinoid receptor inverse agonists.. In: Journal of medicinal chemistry, Vol. 48, no. 23, p. 7486-90 (2005). doi:10.1021/jm0503906.

http://hdl.handle.net/2078.1/10384

Muccioli, Giulio ; Lambert, Didier. Current knowledge on the antagonists and inverse agonists of cannabinoid receptors.. In: Current medicinal chemistry, Vol. 12, no. 12, p. 1361-94 (2005). doi:10.2174/0929867054020891.

http://hdl.handle.net/2078.1/10233

Gbaguidi, F. ; Muccioli, Giulio ; Accrombessi, Georges C. ; Moudachirou, M. ; Quetin-Leclercq, Joëlle. Densitometric HPTLC quantification of 2-azaanthraquinone isolated from Mitracarpus scaber and antimicrobial activity against Dermatophilus congolensis. In: Journal of Planar Chromatography - Modern TLC, Vol. 18, no. 105, p. 377-379 (2005). doi:10.1556/JPC.18.2005.5.8.

http://hdl.handle.net/2078.1/38997

Muccioli, Giulio ; Martin, Diana ; Scriba, Gerhard K E ; Poppitz, Wolfgang ; Poupaert, Jacques ; Wouters, Johan ; Lambert, Didier. Substituted 5,5'-diphenyl-2-thioxoimidazolidin-4-one as CB1 cannabinoid receptor ligands: synthesis and pharmacological evaluation.. In: Journal of medicinal chemistry, Vol. 48, no. 7, p. 2509-17 (2005). doi:10.1021/jm049263k.

http://hdl.handle.net/2078.1/10150

Govaerts, Sophie ; Muccioli, Giulio ; Hermans, Emmanuel ; Lambert, Didier. Characterization of the pharmacology of imidazolidinedione derivatives at cannabinoid CB1 and CB2 receptors.. In: European Journal of Pharmacology, Vol. 495, no. 1, p. 43-53 (2004). doi:10.1016/j.ejphar.2004.05.023.

http://hdl.handle.net/2078.1/9888

Muccioli, Giulio ; Poupaert, Jacques ; Wouters, Johan ; Norberg, Bernadette ; Poppitz, Wolfgang ; Scriba, Gerhard K. E. ; Lambert, Didier. A rapid and efficient microwave-assisted synthesis of hydantoins and thiohydantoins. In: Tetrahedron, Vol. 59, no. 8, p. 1301-1307 (2003). doi:10.1016/S0040-4020(03)00033-4.

http://hdl.handle.net/2078.1/41451

Muccioli, Giulio ; Wouters, Johan ; Poupaert, Jacques ; Norberg, Bernadette ; Poppitz, Wolfgang ; Scriba, Gerhard K E ; Lambert, Didier. Versatile access to benzhydryl-phenylureas through an unexpected rearrangement during microwave-enhanced synthesis of hydantoins.. In: Organic letters, Vol. 5, no. 20, p. 3599-602 (2003). doi:10.1021/ol035282x.

http://hdl.handle.net/2078.1/9632

Al Houayek, Mireille ; Muccioli, Giulio. Pharmacological Aspects of Anandamide and 2-Arachidonoyglycerol as Bioactive Lipids. In: Handbook of Cannabis and Related Pathologies: Biology, Pharmacology, Diagnosis, and Treatment, Elsevier, 2017, 616–629. 978-012800827-0;978-012800756-3. doi:10.1016/B978-0-12-800756-3.00074-0.

http://hdl.handle.net/2078.1/185914