FATH
Avenue Hippocrate 57/B1.57.04
1200 Woluwe-Saint-Lambert
- Accueil
- Répertoire
- Olivier Feron
Olivier Feron
Professeur ordinaire
Faculty positions
1997 Instructor in Medicine, Harvard Medical School, Boston
1999 Assistant Professor, UCLouvain, Brussels
2004 Associate Professor, UCLouvain, Brussels
2008 Professor, UCLouvain, Brussels
2011 Full Professor, UCLouvain, Brussels
FNRS positions
1999 Chercheur qualifié
2005 Maître de recherches
2009 Directeur de recherches
- Diplômes
Année Label Institution 1990 Pharmacien Université catholique de Louvain 1992 Licencié en sciences biomédicales (3ème cycle) Université catholique de Louvain 1995 Docteur en sciences pharmaceutiques Université catholique de Louvain 2004 Agrégé de l'enseignement supérieur Université catholique de Louvain
- Les cours
Nom ID Eléments de physiologie générale WFARM1212 Physiologie des systèmes et éléments de physiopathologie WFARM1213 Eléments de pathologie humaine WFARM1305 Pharmacothérapie intégrée WFARM2111 Pharmacologie spéciale et éléments de pharmacothérapie 1re partie WFARM2114 Pharmacologie spéciale et éléments de pharmacothérapie 2e partie WFARM2116 Organotoxicité et cancer : aspects moléculaires, cellulaires et fonctionnels WFARM2180 Séminaire d'intégration pharmaceutique (finalité approfondie) WFARM2249 Séminaire d'intégration pharmaceutique (finalité spécialisée) WFARM2259 Physiologie générale WSBIM1201 Signalisation intercellulaire et biologie des tumeurs WSBIM2141 Special issues in cancerology WSBIM2244 In-session seminar in biomedicine WSBIM2245
The O. Feron lab is located on the UCLouvain campus in Brussels (Tour Vésale 5th floor). Along the years, the focus of the lab has shifted from cardiovascular diseases to oncology. Current research topics include the study of different aspects of the tumor metabolism impacting on, or influenced by, the tumor microenvironment, in particular hypoxia and acidosis. The lab of Prof. O. Feron has also implemented a technological platform to identify and validate new chemical entities (NCE) and innovative prognostic cancer biomarkers.
Among the most recent discoveries of O. Feron's research group are the link between cycling hypoxia and tumor progression, the role of lactate as a key actor of tumor metabolic symbiosis and the metabolic shift from glucose toward glutamine and fatty acids in response to tumor microenvironment acidosis.
The research group currently consists of 3 post-docs, 6 PhD students and 3 technicians; administrative resources (secretary and account manager) are shared with the other research groups of the FATH Pole.
2025
Richiardone, Elena ; Giolito, Maria Virginia ; Al Roumi, Rim ; Ambroise, Jérôme ; Boidot, Romain ; Drotleff, Bernhard ; Ghesquière, Bart ; Lupo, Barbara ; Trusolino, Livio ; Bardelli, Alberto ; Arena, Sabrina ; Feron, Olivier ; Corbet, Cyril. Acidosis overrides molecular heterogeneity to shape therapeutically targetable metabolic phenotypes in colon cancers. In: Cancer Letters, Vol. 613, no.1, p. 217512 (2025). doi:10.1016/j.canlet.2025.217512.
2025
Van den Bossche, Valentin ; Vignau, Julie ; Vigneron, Engy ; Rizzi, Isabella ; Zaryouh, Hannah ; Wouters, An ; Ambroise, Jérôme ; Van Laere, Steven ; Beyaert, Simon ; Helaers, Raphaël ; van Marcke, Cédric ; Mignion, Lionel ; Lepicard, Elise ; Jordan, Bénédicte ; Guilbaud, Céline ; Lowyck, Olivier ; Dahou, Hajar ; Mendola, Antonella ; Desgres, Manon ; Aubert, Léo ; Gerin, Isabelle ; Bommer, Guido ; Boidot, Romain ; Vermonden, Perrine ; Warnant, Aurélien ; Larondelle, Yvan ; Machiels, Jean-Pascal ; Feron, Olivier ; Schmitz, Sandra ; Corbet, Cyril. PPARα-mediated fatty acid metabolism reprogramming supports resistance to anti-EGFR targeted therapy in head and neck squamous cell carcinoma. In: Nature Communications (Accepté/Sous presse).
2024
Deskeuvre, Marine ; Lan, Junjie ; Messens, Joris ; Riant, Olivier ; Feron, Olivier ; Frédérick, Raphaël. A novel approach to pH-Responsive targeted cancer Therapy: Inhibition of FaDu cancer cell proliferation with a pH low insertion Peptide-Conjugated DGAT1 inhibitor. In: International Journal of Pharmaceutics, Vol. 657, p. 124132 (2024). doi:10.1016/j.ijpharm.2024.124132.
2024
Glowacka, Katarzyna ; Ibanez, Sébastien ; Renoult, Ophélie ; Vermonden, Perrine ; Giolito, Maria Virginia ; Özkan, Kübra ; Degavre, Charline ; Aubert, Léo ; Guilbaud, Céline ; Laloux-Morris, Florine ; Richiardone, Elena ; Ambroise, Jérôme ; Bouzin, Caroline ; Brusa, Davide ; Dehairs, Jonas ; Swinnen, Johan ; Corbet, Cyril ; Larondelle, Yvan ; Feron, Olivier. Acid-exposed and hypoxic cancer cells do not overlap but are interdependent for unsaturated fatty acid resources. In: Nature Communications, Vol. 15, no.1, p. 10107 (2024). doi:10.1038/s41467-024-54435-3.
2024
Degavre, Charline ; Lepez, Anouk ; Ibanez, Sebastien ; François, Clémence ; Głowacka, Katarzyna ; Guilbaud, Céline ; Laloux-Morris, Florine ; Esfahani, Hrag ; Brusa, Davide ; Bouzin, Caroline ; Feron, Olivier. In situ endoscopic photodynamic therapy combined with immature DC vaccination induces a robust T cell response against peritoneal carcinomatosis.. In: Journal for immunotherapy of cancer, Vol. 12, no.11, p. e009752 (2024). doi:10.1136/jitc-2024-009752.
2024
Vermonden, Perrine ; Martin, Manon ; Glowacka, Katarzyna ; Neefs, Ineke ; Ecker, Josef ; Höring, Marcus ; Liebisch, Gerhard ; Debier, Cathy ; Feron, Olivier ; Larondelle, Yvan. Phospholipase PLA2G7 is complementary to GPX4 in mitigating punicic-acid-induced ferroptosis in prostate cancer cells. In: iScience, Vol. 27, no.5, p. 109774 (2024). doi:10.1016/j.isci.2024.109774.
2024
Aubert, Léo ; Bastien, Estelle ; Renoult, Ophélie ; Guilbaud, Céline ; Özkan, Kübra ; Brusa, Davide ; Bouzin, Caroline ; Richiardone, Elena ; Richard, Corentin ; Boidot, Romain ; Léonard, Daniel ; Corbet, Cyril ; Feron, Olivier. Tumor acidosis-induced DNA damage response and tetraploidy: implications for ATM and ATR inhibitors.. In: EMBO Reports, Vol. 25, no. 3, p. 1469-1489 (2024).
2024
Lefevre, Camille ; Thibaut, Morgane ; Loumaye, Audrey ; Thissen, Jean-Paul ; Neyrinck, Audrey M. ; Navez, Benoît ; Delzenne, Nathalie M. ; Feron, Olivier ; Bindels, Laure B.. Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis.. In: Molecular metabolism, Vol. 83, p. 101930 [1-18] (2024). doi:10.1016/j.molmet.2024.101930.
2023
Feron, Olivier ; Chang, Chih-Hao ; Végran, Frédérique. Editorial: Targeting glucose metabolism in cancer immunity and immunotherapy.. In: Frontiers in immunology, Vol. 14, p. 1171274 [1-2] (2023). doi:10.3389/fimmu.2023.1171274.
2023
Feron, Olivier ; Chang, Chih-Hao ; Végran, Frédérique. Editorial: Targeting glucose metabolism in cancer immunity and immunotherapy.. In: Frontiers in immunology, Vol. 14, no.(), p. 1171274 (2023). doi:10.3389/fimmu.2023.1171274.
2023
Moghassemi, Saeid ; Dadashzadeh, Arezoo ; Camboni, Alessandra ; Feron, Olivier ; Azevedo, Ricardo Bentes ; Andrade Amorim, Christiani. Ex vivo purging of cancer cells from ovarian tissue using photodynamic therapy: a novel strategy to restore fertility in leukemia patients.. In: Human reproduction open, Vol. 2023, no. 2, p. hoad005 [1-13] (2023). doi:10.1093/hropen/hoad005.
2023
Cuvelier, Géraldine ; Vermonden, Perrine ; Rousseau, Justine ; Feron, Olivier ; Rezsohazy, René ; Larondelle, Yvan. Resistance to CLnA-induced ferroptosis is acquired in Caco-2 cells upon differentiation. In: Frontiers in Cell Death, Vol. 2, no.1, p. 1 (2023). doi:10.3389/fceld.2023.1219672.
2023
Tan, Yonghua ; Lefevre, Marine ; Pierrard, François ; Soetens, Mathieu ; Shoueiry, Maria ; Yildiz, Esra ; Ibanez, Sébastien ; Ozkan, Kubra ; Feron, Olivier ; Frédérick, Raphaël ; Riant, Olivier. Tandem Heck/Tsuji-Trost Reaction for Uncaging of Alloc-Protected Amines with Palladium Complexes in Living Cells. In: Journal of Organometallic Chemistry, Vol. 996, no.-, p. 122743 (2023). doi:10.1016/j.jorganchem.2023.122743.
2023
Dilly, Sébastien ; Romero Toledo, Miguel ; Solier, Stéphanie ; Feron, Olivier ; Dessy, Chantal ; Slama Schwok, Anny. Targeting M2 Macrophages with a Novel NADPH Oxidase Inhibitor.. In: Antioxidants (Basel, Switzerland), Vol. 12, no.2, p. 440 [1-16] (2023). doi:10.3390/antiox12020440.
2022
Lan, Junjie ; Cadassou, Octavia ; Corbet, Cyril ; Riant, Olivier ; Feron, Olivier. Discovery of Mitochondrial Complex I Inhibitors as Anticancer and Radiosensitizer Drugs Based on Compensatory Stimulation of Lactate Release. In: Cancers, Vol. 14, no. 21, p. 5454 [1-15] (2022). doi:10.3390/cancers14215454.
2022
Sancho, Patricia ; Feron, Olivier. Editorial: Insights in pharmacology of anti-cancer drugs: 2021.. In: Frontiers in pharmacology, Vol. 13, p. 1062640 [1-2] (2022). doi:10.3389/fphar.2022.1062640.
2022
Catanzaro, Elena ; Feron, Olivier ; Skirtach, André G ; Krysko, Dmitri V. Immunogenic Cell Death and Role of Nanomaterials Serving as Therapeutic Vaccine for Personalized Cancer Immunotherapy.. In: Frontiers in immunology, Vol. 13, p. 925290 [1-18] (2022). doi:10.3389/fimmu.2022.925290.
2022
Van de Gucht, Melissa ; Dufait, Inès ; Kerkhove, Lisa ; Corbet, Cyril ; de Mey, Sven ; Jiang, Heng ; Law, Ka Lun ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Inhibition of Phosphoglycerate Dehydrogenase Radiosensitizes Human Colorectal Cancer Cells under Hypoxic Conditions. In: Cancers, Vol. 14, no. 20, p. 5060 [1-17] (2022). doi:10.3390/cancers14205060.
2022
Johanns, Manuel ; Corbet, Cyril ; Jacobs, Roxane ; Drappier, Melissa ; Bommer, Guido ; Herinckx, Gaëtan ; Vertommen, Didier ; Tajeddine, Nicolas ; Young, David ; Messens, Joris ; Feron, Olivier ; Steinberg, Gregory R ; Hue, Louis ; Rider, Mark H.. Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators.. In: The Biochemical journal, Vol. 479, no. 12, p. 1317-1336 (2022). doi:10.1042/BCJ20220170.
2022
Moghassemi, Saeid ; Dadashzadeh, Arezoo ; Camboni, Alessandra ; Feron, Olivier ; Azevedo, Ricardo Bentes ; Andrade Amorim, Christiani. Photodynamic therapy using OR141-loaded nanovesicles for eradication of leukemic cells from ovarian tissue.. In: Photodiagnosis and photodynamic therapy, Vol. 40, no.-, p. 103139 (2022). doi:10.1016/j.pdpdt.2022.103139.
2022
Deskeuvre, Marine ; Lan, Junjie ; Dierge, Emeline ; Messens, Joris ; Riant, Olivier ; Corbet, Cyril ; Feron, Olivier ; Frédérick, Raphaël. Targeting cancer cells in acidosis with conjugates between the carnitine palmitoyltransferase 1 inhibitor etomoxir and pH (low) insertion peptides. In: International Journal of Pharmaceutics, Vol. 624, no.1, p. 122041 (2022). doi:10.1016/j.ijpharm.2022.122041.
2022
Delprat, Victor ; Huart, Camille ; Feron, Olivier ; Soncin, Fabrice ; Michiels, Carine. The impact of macrophages on endothelial cells is potentiated by cycling hypoxia: Enhanced tumor inflammation and metastasis.. In: Frontiers in oncology, Vol. 12, p. 961753 [1-14] (2022). doi:10.3389/fonc.2022.961753.
2021
Valenti, Maria Teresa ; Mottes, Monica ; Dalle Carbonare, Luca ; Feron, Olivier. Editorial: Bone Metastases.. In: Frontiers in oncology, Vol. 11, p. 741515 (2021). doi:10.3389/fonc.2021.741515.
2021
Buyse, Chloé ; Joudiou, Nicolas ; Corbet, Cyril ; Feron, Olivier ; Mignion, Lionel ; Flament, Julien ; Gallez, Bernard. Impact of Inhibition of the Mitochondrial Pyruvate Carrier on the Tumor Extracellular pH as Measured by CEST-MRI. In: Cancers, Vol. 13, no.17, p. 4278 (2021). doi:10.3390/cancers13174278.
2021
Virga, Federico ; Cappellesso, Federica ; Stijlemans, Benoit ; Henze, Anne-Theres ; Trotta, Rosa ; Van Audenaerde, Jonas ; Mirchandani, Ananda S. ; Sanchez-Garcia, Manuel A. ; Vandewalle, Jolien ; Orso, Francesca ; Riera-Domingo, Carla ; Griffa, Alberto ; Ivan, Cristina ; Smits, Evelien ; Laoui, Damya ; Martelli, Fabio ; Langouche, Lies ; Van den Berghe, Greet ; Feron, Olivier ; Ghesquière, Bart ; Prenen, Hans ; Libert, Claude ; Walmsley, Sarah R. ; Corbet, Cyril ; Van Ginderachter, Jo A. ; Ivan, Mircea ; Taverna, Daniela ; Mazzone, Massimiliano. Macrophage miR-210 induction and metabolic reprogramming in response to pathogen interaction boost life-threatening inflammation. In: Science Advances, Vol. 7, no.19, p. eabf0466 (2021). doi:10.1126/sciadv.abf0466.
2021
Dierge, Emeline ; Debock, Elena ; Guilbaud, Céline ; Corbet, Cyril ; Mignolet, Eric ; Mignard, Louise ; Bastien, Estelle ; Dessy, Chantal ; Larondelle, Yvan ; Feron, Olivier. Peroxidation of n-3 and n-6 polyunsaturated fatty acids in the acidic tumor environment leads to ferroptosis-mediated anticancer effects. In: Cell Metabolism, Vol. S1550-4131, no.21, p. 00233-3 (2021). doi:10.1016/j.cmet.2021.05.016.
2021
Moghassemi, Saeid ; Dadashzadeh, Arezoo ; Azevedo, Ricardo Bentes ; Feron, Olivier ; Amorim, Christiani A. Photodynamic cancer therapy using liposomes as an advanced vesicular photosensitizer delivery system.. In: Journal of controlled release : official journal of the Controlled Release Society, Vol. 339, p. 75-90 (2021). doi:10.1016/j.jconrel.2021.09.024 (Accepté/Sous presse).
2021
Vermonden, Perrine ; Vancoppenolle, Matthias ; Dierge, Emeline ; Mignolet, Eric ; Cuvelier, Géraldine ; Knoops, Bernard ; Page, Melissa ; Debier, Cathy ; Feron, Olivier ; Larondelle, Yvan. Punicic Acid Triggers Ferroptotic Cell Death in Carcinoma Cells. In: Nutrients, Vol. 13, no. 8, p. 2751 [1-16] (2021). doi:10.3390/nu13082751.
2021
Vander Linden, Catherine ; Corbet, Cyril ; Bastien, Estelle ; Martherus, Ruben ; Guilbaud, Céline ; Petit, Laurenne ; Wauthier, Loris ; Loriot, Axelle ; De Smet, Charles ; Feron, Olivier. Therapy-induced DNA methylation inactivates MCT1 and renders tumor cells vulnerable to MCT4 inhibition. In: Cell Reports, Vol. 35, no.9, p. 109202 (2021). doi:10.1016/j.celrep.2021.109202.
2021
Spillier, Quentin ; Ravez, Séverine ; Dochain Simon ; Vertommen, Didier ; Thabault, Léopold ; Feron, Olivier ; Frédérick, Raphaël. Unravelling the Allosteric Targeting of PHGDH at the ACT-Binding Domain with a Photoactivatable Diazirine Probe and Mass Spectrometry Experiments. In: Molecules, Vol. 26, no. 2, p. 477 (2021). doi:10.3390/molecules26020477.
2020
Yelek, Caner ; Mignion, Lionel ; Joudiou, Nicolas ; Terrasi, Romano ; Gourgue, Florian ; Van Hul, Matthias ; Delzenne, Nathalie M. ; Gallez, Bernard ; Corbet, Cyril ; Muccioli, Giulio ; Feron, Olivier ; Cani, Patrice D. ; Jordan, Bénédicte. Acetate: Friend or foe against breast tumour growth in the context of obesity?. In: Journal of Cellular and Molecular Medicine, Vol. 24, no. 24, p. 14195-14204 (2020). doi:10.1111/jcmm.16034.
2020
Trempolec, Natalia ; Degavre, Charline ; Doix, Bastien ; Brusa, Davide ; Corbet, Cyril ; Feron, Olivier. Acidosis-Induced TGF-β2 Production Promotes Lipid Droplet Formation in Dendritic Cells and Alters Their Potential to Support Anti-Mesothelioma T Cell Response. In: Cancers, Vol. 12, no. 5, p. 1284 [1-17] (2020). doi:10.3390/cancers12051284.
2020
Schoonjans, Céline ; Joudiou, Nicolas ; Brusa, Davide ; Corbet, Cyril ; Feron, Olivier ; Gallez, Bernard. Acidosis-induced metabolic reprogramming in tumor cells enhances the anti-proliferative activity of the PDK inhibitor dichloroacetate. In: Cancer Letters, Vol. 470, p. 18-28 (2020). doi:10.1016/j.canlet.2019.12.003.
2020
Dierge, Emeline ; Larondelle, Yvan ; Feron, Olivier. Cancer diets for cancer patients: Lessons from mouse studies and new insights from the study of fatty acid metabolism in tumors. In: Biochimie, Vol. 178, p. 56-68 (2020). doi:10.1016/j.biochi.2020.08.020.
2020
Delprat, Victor ; Tellier, Céline ; Demazy, Catherine ; Raes, Martine ; Feron, Olivier ; Michiels, Carine. Cycling hypoxia promotes a pro-inflammatory phenotype in macrophages via JNK/p65 signaling pathway. In: Scientific Report, Vol. 10, no. 1, p. 882 (2020).
2020
de Mey, Sven ; Dufait, Inès ; Jiang, Heng ; Corbet, Cyril ; Wang, Hui ; Van De Gucht, Melissa ; Kerkhove, Lisa ; Law, Ka Lun ; Vandenplas, Hugo ; Gevaert, Thierry ; Feron, Olivier ; De Ridder, Mark. Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells. In: International Journal of Molecular Sciences, Vol. 21, no.24, p. 9367 (2020). doi:10.3390/ijms21249367.
2020
Fourniols, Thibaut ; Bastien, Estelle ; Canevat, Alizée ; Feron, Olivier ; Préat, Véronique. Inhibition of colorectal cancer-associated fibroblasts by lipid nanocapsules loaded with acriflavine or paclitaxel.. In: International journal of pharmaceutics, Vol. 584, p. 119337 (2020). doi:10.1016/j.ijpharm.2020.119337 (Accepté/Sous presse).
2020
Mignion, Lionel ; Acciardo, Stefania ; Gourgue, Florian ; Joudiou, Nicolas ; Caignet, Xavier ; Goebbels, Rose-Marie ; Corbet, Cyril ; Feron, Olivier ; Bouzin, Caroline ; Cani, Patrice D. ; Machiels, Jean-Pascal ; Schmitz, Sandra ; Jordan, Bénédicte. Metabolic imaging using hyperpolarized pyruvate-lactate exchange assesses response or resistance to the EGFR inhibitor cetuximab in patient-derived HNSCC xenografts.. In: Clinical cancer research, Vol. 15, no. 26(8), p. 1932-1943 (2020). doi:10.1158/1078-0432.CCR-19-1369.
2020
Gourgue, Florian ; Mignion, Lionel ; Van Hul, Matthias ; Dehaen, Natacha ; Bastien, Estelle ; Payen, Valery ; Leroy, Baptiste ; Joudiou, Nicolas ; Vertommen, Didier ; Bouzin, Caroline ; Delzenne, Nathalie M. ; Gallez, Bernard ; Feron, Olivier ; Jordan, Bénédicte ; Cani, Patrice D.. Obesity and triple-negative-breast-cancer: Is apelin a new key target?. In: Journal of cellular and molecular medicine, Vol. 24, p. 10233-44 (2020). doi:10.1111/jcmm.15639.
2020
Trempolec, Natalia ; Doix, Bastien ; Degavre, Charline ; Brusa, Davide ; Bouzin, Caroline ; Riant, Olivier ; Feron, Olivier. Photodynamic Therapy-Based Dendritic Cell Vaccination Suited to Treat Peritoneal Mesothelioma. In: Cancers, Vol. 12, no. 3, p. pii:E545 (2020).
2020
Ward, Jennifer A ; Pinto-Fernandez, Adan ; Cornelissen, Loïc ; Bonham, Sarah ; Díaz-Sáez, Laura ; Riant, Olivier ; Huber, Kilian V M ; Kessler, Benedikt M ; Feron, Olivier ; Tate, Edward W. Re-evaluating the mechanism of action of α,β-unsaturated carbonyl DUB inhibitors b-AP15 and VLX1570: a paradigmatic example of unspecific protein crosslinking with Michael acceptor motif-containing drugs.. In: Journal of medicinal chemistry, Vol. 63, no. 7, p. 3756-3762 (2020). doi:10.1021/acs.jmedchem.0c00144.
2020
Spillier, Quentin ; Ravez, Severine ; Unterlass, Judith ; Corbet, Cyril ; Degavre, Charline ; Feron, Olivier ; Frédérick, Raphaël. Structure–Activity Relationships (SARs) of α-Ketothioamides as Inhibitors of Phosphoglycerate Dehydrogenase (PHGDH). In: Pharmaceuticals, Vol. 13, no.2, p. 20 (2020). doi:10.3390/ph13020020.
2020
Corbet, Cyril ; Bastien, Estelle ; Santiago de Jesus, Joao Pedro ; Dierge, Emeline ; Martherus, Ruben ; Vander Linden, Catherine ; Doix, Bastien ; Degavre, Charline ; Guilbaud, Céline ; Petit, Laurenne ; Michiels, Carine ; Dessy, Chantal ; Larondelle, Yvan ; Feron, Olivier. TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. In: Nature Communications, Vol. 11, no.1, p. 1 (2020). doi:10.1038/s41467-019-14262-3.
2020
Schoonjans, Céline A ; Mathieu, Barbara ; Joudiou, Nicolas ; Zampieri, Luca X ; Brusa, Davide ; Sonveaux, Pierre ; Feron, Olivier ; Gallez, Bernard. Targeting Endothelial Cell Metabolism by Inhibition of Pyruvate Dehydrogenase Kinase and Glutaminase-1.. In: Journal of clinical medicine, Vol. 9, no.10, p. 14pp (2020). doi:10.3390/jcm9103308.