Principal Investigator, Professor of Pharmacology, F.R.S.-FNRS Senior Research Associate

Education

Function

Director of the team Tumor Metabolism (TUMETABO)

#Patents

#Honors and awards

#Publications

Patents

1. Sonveaux P, Dessy C, Feron O. Use of endothelin-1 antagonists for improving cancer therapy. Priority date: 15 May 2003. Filling number: 60/470,679. Publication number: WO2004100991 A1.

2. Li CY, Li F, Sonveaux P, Dewhirst MW. Inhibition of HIF-1 activation for anti-tumor and anti-inflammatory responses. Priority date: 30 March 2006. Filling number: 60/787,373. Publication number: US 2007/0297984 A1. 

3. Dewhirst MW, Sonveaux P, Feron O, Schroeder T, Wahl ML. Use of agents that inhibit cancer growth by simultaneously targeting tumor cell metabolism and angiogenesis. Priority date: 05 February 2007. Filling number: US provisional patent application n°2796.

Honors and Awards

2016 1st Prize for best oral presentation, BACR (Valéry Payen)
2015 Best poster award, Rencontre des chercheurs du Télévie (M Sboarina)
2015 Alvarenga de Piauhy Prize, Royal Academy of Medicine of Belgium (PE Porporato)
2015 Pharmacist and Doctor Nedeljkovic Award (C Dethier)
2015 Best Undergraduate Thesis Award (C Dethier)
2015 Excellent Poster Award and JPY 100 000 YTR Travel Award, ICRR2015 (B. Baselet) 
2014 Best poster award, IREC PhD day (V. Van Hée)
2014 Officer in the Order of the Walloon Merit (P. Sonveaux)
2014 Appointed Patron of the 10th Allan Sport – Télévie challenge (P. Sonveaux)
2014 Young Investigator Award, ERRS (B. Baselet)
2014 Best poster award, BACR (VL Payen)
2013 Doctor Jean Oscar Maes Prize, Health Sciences Sector, UCL (P Sonveaux)
2013 Pharmacist and Doctor Nedeljkovic Award (VL Payen)
2013 Best graduation thesis award, student-researchers (VL Payen)
2013 Albert Pierre-Jean Dustin Prize, Royal Academy of Medicine of Belgium (P Sonveaux)
2013 Cornélis-Lebègue Prize, Royal Academy of Medicine of Belgium (P Sonveaux)
2013 Best poster award, BACR (CJ De Saedeleer)
2012 Clément Perdieus-Cécile Petit Prize 2009-2012, Health Sciences Sector, UCL (P Sonveaux)
2012 Triple 1st best academic communication prize ex-aequo, Biowin (CJ De Saedeleer, VL Payen, PE Porporato)
2012 Trainee award, Aegean Conferences (PE Porporato)
2012 Trainee award, Aegean Conferences (CJ De Saedeleer)
2012 Elected ISPDC Board Member (P Sonveaux)
2011 EACR Special Lecture Award (P Sonveaux)
2010 1st Henryk S. Taper Lecture, UK (P Sonveaux)
2010 Galien Prize in Pharmacology, Brussels, Belgium. (P Sonveaux)
2010 Highly Commended Award, EACR (P Sonveaux)
2010 Burgen Scholarship, Academia Europaea (P Sonveaux)
2010 Ferdinand Depelchin Prize 2007-2010, UCL Faculty of Medicine (P Sonveaux)
2008 Henri Fauconnier Prize, Royal Academy of Medicine of Belgium (P Sonveaux)
2008 Federation of European Cancer Societies - European Journal of Cancer (FECS-EJC) Award (P. Sonveaux)

Publications

1. Gérard AC, Poncin S, Caetano B, Sonveaux P, Audinot JN, Feron O, Colin IM, Soncin F. Iodine deficiency induces a thyroid stimulating hormone-independent early phase of microvascular reshaping in the thyroid. Am. J. Pathol. 2008;172(3):748-760.
2. Frérart F,* Sonveaux P,* Rath G, Smoos A, Meqor A, Charlier N, Jordan BF, Saliez J, Noël A, Dessy C, Gallez B, Feron O. *Shared first authorship. The acidic tumor microenvironment promotes the reconversion of nitrite into nitric oxide: towards a new and safe radiosensitizing strategy. Clin. Cancer Res. 2008;14(7):2768-2774.
3. Sonveaux P, Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, De Saedeleer CJ, Kennedy KM, Diepart C, Jordan BF, Kelley MJ, Gallez B, Wahl MW, Feron O, Dewhirst MW.  Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J. Clin. Invest. 2008;118(12):3930-3942.
4. Sonveaux P. Provascular strategy: targeting functional adaptations of mature blood vessels in tumors to selectively influence the tumor vascular reactivity and improve cancer treatment. Radiother. Oncol. 2008;86(3):300-313.
5. Sonveaux P, Jordan BF, Gallez B, Feron O. Nitric oxide delivery to cancer: why and how? Eur. J. Cancer 2009;45(8):1352-1369.
6. Jiang H, De Ridder M, Verovski VN, Sonveaux P, Jordan BF, Law K, Monsaert C, Van den Berge DL, Verellen D, Feron O, Gallez B, Storme GA. Activated macrophages as a novel determinant of tumor cell radioresponse: the role of nitric oxide-mediated inhibition of cellular respiration and oxygen sparing. Int. J. Radiat. Oncol. 2010;76(5):1520-1527.
7. Moon EJ, Sonveaux P, Nien YCC, Schroeder T, Dewhirst MW. NADPH oxidase-mediated ROS production activates HIF-1 via the ERK pathway after hyperthermia treatment. P. Natl. Acad. Sci. U.S.A. 2010;107(47):20477-20482. 
8. Sonveaux P. Loss of CC3/TIP30 allows tumor cells to cope with low glucose. Cell Cycle 2011;10(3):376. 
9. Végran F, Boidot R, Michiels C, Sonveaux P, Feron O. Lactate influx through endothelial cell monocarboxylate transporter MCT1 promotes a NFB/IL-8 pathway driving tumor angiogenesis. Cancer Res. 2011; 71(7):2550-2560. 
10. Godechal Q, Defresne F, Danhier P, Leveque P, Porporato PE, Sonveaux P, Baurain JF, Feron O, Gallez B. Assessment of melanoma extent and melanoma metastases invasion using electron paramagnetic resonance and bioluminescence imaging. Contrast Media Mol. I. 2011;6(4):282-288. 
11. Porporato PE, Dadhich RK, Dhup S, Copetti T, Sonveaux P. Anticancer targets in the glycolytic metabolism of tumors: a comprehensive review. Front. Pharmacol. 2011;2:49. 
12. Boidot R, Végran F, Meulle A, Sonveaux P, Lizard-Nacol S, Feron O. Regulation of monocarboxylate transporter MCT1 expression by p53 mediates inward and outward lactate fluxes in tumors. Cancer Res. 2012;72:939-948. 
13. Sonveaux P,* Copetti T, De Saedeleer CJ, Végran F, Verrax J, Kennedy KM, Moon EJ, Dhup S, Danhier P, Frérart F, Gallez B, Ribeiro A, Michiels C, Dewhirst MW, Feron O. *Corresponding author. Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. Plos ONE 2012;7(3):e33418. 
14. Végran F, Seront E, Sonveaux P, Feron O. Lactate-induced IL-8 pathway in endothelial cells – Response Cancer Res.2012;72(7):1903-1904. 
15. Danhier P, De Preter G, Boutry S, Mahieu I, Leveque P, Magat J, Haufroid V, Sonveaux P, Bouzin C, Feron O, Muller RM, Jordan BF, Gallez B. Electron paramagnetic resonance as a sensitive tool to assess the iron oxide content in cells for MRI cell labeling studies. Contrast Media Mol. I. 2012;7(3):302-307. 
16. Gerard AC, Humblet K, Wilvers C, Poncin S, Derradji H, de Ville de Goyet C, Abou-el-Ardat K, Baatout S, Sonveaux P, Denef JF, Colin IM. Iodine deficiency-induced long lasting angiogenic reaction in thyroid cancers occurs via a VEGF-HIF-1, but not a ROS dependent pathway. Thyroid 2012;22(7):699-708. 
17. Porporato PE, Payen VL, De Saedeleer CJ, Préat V, Thissen JP, Feron O, Sonveaux P. Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice. Angiogenesis 2012;15:581-592. 
18. Karroum O, Kengen J, Danhier P, Magat J, Mignion L, Bouzin C, Verrax J, Charette N, Starkel P, Calderon BP, Sonveaux P, Feron O, Grégoire V, Gallez B, Jordan BF. Tumor reoxygenation following administration of mitogen-activated protein kinase inhibitors: a rationale for combination with radiation therapy. Radiother. Oncol. 2012;105(1):64-71.
19. Bindels LB, Porporato PE, Dewulf EM, Verrax J, Neyrinck AM, Martin JC, Scott KP, Buc Calderon P, Feron O, Muccioli GG, Sonveaux P,* Cani PD,* Delzenne NM. *Shared authorship. Gut microbiota-derived propionate reduces cancer cell proliferation in the liver. Brit. J. Cancer. 2012;107(8):1337-44.
20. De Saedeleer CJ, Copetti T, Porporato PE, Verrax J, Feron O, Sonveaux P. Lactate activates HIF-1 in oxidative but not in Warburg-phenotype tumor cells. Plos ONE 2012;7(10):e46571.
21. Dhup S, Dadhich RK, Porporato PE, Sonveaux P. Multiple biological activities of lactic acid in cancer: influences on tumor growth, angiogenesis and metastasis. Curr. Pharm. Design 2012;18(10):1319-1330.
22. Jordan BF, Sonveaux P. Targeting tumor perfusion and oxygenation to improve the outcome of anticancer therapy. Front. Pharmacol. 2012;3:94. JCRIF2014: 3.802 
23. Danhier P, Copetti T, De Preter G, Leveque P, Feron O, Jordan BF, Sonveaux P, Gallez B. Influence of cell detachment on the respiration rate of tumor and endothelial cells. Plos ONE 2013;8(1):e53324.
24. Hick AC, Delmarcelle AS, Bouquet M, Klotz S, Copetti T, Forez C, Van Der Smissen P, Sonveaux P, Collet JF, Feron O, Courtoy PJ, Pierreux CE. Reciprocal epithelial:endothelial paracrine interactions during thyroid development govern follicular organization and C-cells differentiation. Dev. Biol. 2013;381(1):227-240.
25. Kennedy KM, Scarbrough PM, Ribeiro A, Richardson R, Yuan H, Sonveaux P, Landon CD, Chi JT, Pizzo S, Schroeder T, Dewhirst MW. Catabolism of exogenous lactate reveals it as a legitimate metabolic substrate in breast cancer. Plos ONE2013:8(9):e75154.
26. Danhier P, De Saedeleer CJ, Karroum O, De Preter G, Jordan BF, Gallez B, Sonveaux P. Optimization of tumor radiotherapy with modulators of cell metabolism: towards clinical applications. Semin. Radiat. Oncol. 2013;23(4):262-272.
27. Draoui D, Schicke O, Fernandes A, Drozak X, Nahra F, Dumont A, Douxfils J, Hermans E, Dogné JM, Corbau R, Marchand A, Chaltin P, Sonveaux P, Feron O, Riant O. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg. Med. Chem. 2013;21(22):7107-7117.
28. De Meester C, Timmermans AD, Balteau M, Ginion A, Roelants V, Noppe G, Porporato PE, Sonveaux P, Viollet B, Sakamoto K, Feron O, Horman S, Vanoverschelde JL, Beauloye C, Bertrand L. Role of AMP-activated protein kinase in regulating hypoxic survival and proliferation of mesenchymal stem cells. Cardiovas. Res. 2014;101(1):20-29.
29. De Saedeleer CJ, Porporato PE, Copetti T, Pérez-Escuredo J, Payen VL, Brisson L, Feron O, Sonveaux P. Glucose deprivation increases monocarboxylate transporter 1 (MCT1) expression and MCT1-dependent tumor cell migration. Oncogene2014;33(31);4060-4068.
30. Steinstraesser L, Lam MC, Jacobsen F, Porporato PE, Cherredy KK, Becerikli M, Stricker I, Hancock REW, Lehnhardt M, Sonveaux P, Préat V, Vandermeulen G. Skin electroporation of a plasmid encoding hCAP-18/LL-37 host defense peptide promotes wound healing. Mol. Ther. 2014;22(4):734-742.
31. Danhier P, De Preter G, Magat J, Godechal Q, Porporato PE, Jordan BF, Feron O, Sonveaux P, Gallez B. Multimodal cell tracking of a spontaneous metastasis model: comparison between MRI, electron paramagnetic resonance and bioluminescence. Contrast Media Mol. I. 2014;9(2):143-153.
32. Draoui N, Schicke O, Seront E, Bouzin C, Sonveaux P, Riant O, Feron O. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol. Cancer. Ther. 2014;13(6):1410-1418.
33. Porporato PE, Payen VL, Pérez-Escuredo J, De Saedeleer CJ, Danhier P, Copetti T, Dhup S, Tardy M, Vazeille T, Bouzin C, Feron O, Michiels C, Gallez B, Sonveaux P. A mitochondrial switch promotes tumor metastasis. Cell Reports 2014;8:754-766.
34. Cherredy KK, Her CH, Comune M, Moia C, Lopes A, Porporato PE, Vanacker J, Lam MC, Steinstraesser L, Sonveaux P, Zhu H, Ferreira LS, Vandermeulen G, Préat V. PLGA nanoparticles loaded with host defense peptide LL37 promote wound healing. J. Control. Rel. 2014;194:138-147.
35. Porporato E, Sonveaux P. Paving the way for a therapeutic prevention of tumor metastasis with agents targeting mitochondrial superoxide. Mol. Cell. Oncol. 2014;2(3):e968043. 
36. Spugnini E, Sonveaux P, Stock CM, Perez-Sayans M, De Milito A, Avnet S, Garcia AG, Harguidey S, Fais S. Implication of proton channels and exchangers in cancer. BBA Biomembranes 2014;1848 (10PtB):2715-2726.
37. Bol V, Bol A, Bouzin C, Labar D, Lee JA, Janssens G, Porporato PE, Sonveaux P, Feron O, Grégoire V. Reprogramming of tumor metabolism by targeting mitochondria improves tumor response to irradiation. Acta Oncol. 2015;54(2)266-274.
38. Craps J, Wilvers C, Joris V, Vanderstraeten J, De Jongh B, Lobysheva I, Balligand JL, Sonveaux P, Gilon P, Many MC, Gerard AC, Colin IM. Involvement of nitric oxide in iodine deficiency-induced microvascular remodeling in the thyroid gland: role of nitric oxide synthase 3 and ryanodine receptors. Endocrinology 2015;156(2):707-720.
39. Danhier F, Danhier P, De Saedeleer CJ, Fruytier AC, Schleich N, des Rieux A, Sonveaux P, Gallez B, Préat V. Paclitaxel-loaded micelles enhance transvascular permeability and retention of nanomedicines in tumors. Int. J. Pharm. 2015;479(2):399-407.
40. Danhier P, Magat J, Leveque P, De Preter G, Porporato PE, Bouzin C, Jordan BF, Demeur G, Haufroid V, Feron O, Sonveaux P, Gallez B. In vivo visualization and ex vivo quantification of murine cancer cells in the brain using MRI cell tracking and electron paramagnetic resonance. NMR Biomed. 2015;28(3):367-375.
41. Payen VL, Brisson L, Dewhirst MW, Sonveaux P. Common responses of tumors and wounds to hypoxia. Cancer J.2015;21(2):75-87.
42. Chereddy KK, Lopes A, Koussoroplis S, Payen VL, Moia C, Zhu H, Sonveaux P, Carmeliet P, des Rieux A, Vermeulen G, Preat V. Combined effects of PLGA and vascular endothelial growth factor promote the healing of non-diabetic and diabetic wounds. Nanomed. 2015;11(8):1975-1984.
43. Van Hée VF, Pérez-Escuredo J, Cacace A, Copetti T, Sonveaux P. Lactate does not activate NF-κB in oxidative tumor cells. Front. Pharmacol. 2015;6:228.
44. De Preter G, Neveu MA, Danhier P, Brisson L, Payen VL, Porporato PE, Jordan BF, Sonveaux P, Gallez B. Inhibition of the pentose phosphate pathway by dichloroacetate unravels a missing link between aerobic glycolysis and cancer cell proliferation. Oncotarget 2015;7(3):2910-2920.
45. Mignion L, Danhier P, Porporato PE, Magat J, Grégoire V, Sonveaux P, Gallez B, Jordan BF. Non-invasive in vivo imaging of early metabolic tumor responses to therapies targeting choline signaling. Int. J. Cancer, 2016;138(8):2043-2049.
46. De Preter G, Deriemaeker C, Danhier P, Brisson L, Cao Pham TT, Grégoire V, Jordan BF, Sonveaux P, Gallez B. A fast hydrogen sulfide-releasing donor increases the tumor response to radiotherapy. Mol. Cancer Ther 2016;15(1):154-161.
47. Pérez-Escuredo J, Dadhish RK, Dhup S, Van Hée V, Rodriguez F, Fontenille MJ, Brisson L, Porporato PE, Sonveaux P. Lactate promotes glutaminolysis in oxidative cancer cells. Cell Cycle 2016;15(1):72-83.
48. Desmet C, Lafosse A, Vériter S, Porporato PE, Sonveaux P, Dufrasne D, Leveque P, Gallez B. Application of electron paramagnetic resonance (EPR) oximetry to monitor oxygen in wounds in diabetic models. PloS ONE 2016;10(12):e0144914.
49. Vanderstraeten J, Derradji H, Craps J, Sonveaux P, Colin I, Many MC, Gérard AC. Iodine deficiency induces a VEGF-dependent microvascular response in salivary glands and in the stomach. Histol. Histopathol. 2016:11727.
50. Payen VL, Porporato PE, Baselet B, Sonveaux P. Metabolic changes associated with tumor metastasis, part 1: tumor pH, glycolysis and the pentose phosphate pathway. Cell Mol. Life Sci. 2016;73(7):1333-1348.
51. Porporato PE, Payen VL, Baselet B, Sonveaux P. Metabolic changes associated with tumor metastasis, part 2: mitochondria, lipid and amino acid metabolism. Cell Mol. Life Sci. 2016; 73(7):1349-1363.
52. De Preter G, Danhier P, Porporato PE, Payen VL, Jordan BF, Sonveaux P, Gallez B. Direct evidence of the link between energetic metabolism and proliferation capacity of cancer cells in vitro. Adv. Exp. Med. Biol. 2016;876:209-214.
53. Baldini N, Sonveaux P, De Milito A, Supuran C, Otto A, Stock C, Pedersen SF, Favicchio R, Avnet S. Metabolism and microenvironment in cancer plasticity. Cancer Metab. 2016; 4(Suppl 1):1.
54. Chano T, Avnet S, Kusazaki K, Salerno M, Bonuccelli G, Sonveaux P, Rotili D, Mai A, Baldini N. Tumour-specific metabolic adaptation to acidosis is coupled to epigenetic stability in osteosarcoma cells. Am. J. Cancer Res. 2016;6(4):859-875.
55. Craps J, Joris V, De Jongh B, Sonveaux P, Horman S, Lengele B, Bertrand L, Many MC, Colin IM, Gerard AC. Involvement of mTOR and regulation by AMPK in TSH-independent iodine deficiency-induced thyroid microvascular activation. Endocrinology2016;157(6):2545-2559.
56. Sonveaux P, Maechler P, Martinou JC. Channels and transporters in cell metabolism. BBA Mol. Cell Res. 2016; doi: 10.1016/j.bbamcr.2016.06.001.
57. Pérez-Escuredo J, Van Hée VF, Sboarina M, Falces J, Payen VL, Pellerin L, Sonveaux P. Monocarboxylate transporters in the brain and in cancer. BBA Mol. Cell Res. 2016; doi: 10.1016/j.bbamcr.2016.03.013.