LDRI
Avenue Mounier 73/B1.73.11
1200 Woluwe-Saint-Lambert
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Laure Bindels
Professeure
- ESPEN Research Fellowship (2015-2018)
- Prix Docteur Maurice Godin-Maria Savelkoul (triennial prize from the Académie royale de Médecine de Belgique) (2016)
- Scholarship for the Next Gen Immunology 2016 meeting sponsored by the Weizmann Systems Biology initiative (2016)
- Award Danone Institute for the best popular article in nutrition (2015)
- Young Investigator Award from the Society on Cachexia and Wasting Disorders (2015)
- Nebraska Gateway to Nutrigenomics Research Award (2014)
- Honorary Fellowship from the B.A.E.F. (Belgian American Education Foundation) (2014)
- Early Career Investigator Travel Fellowship from the New York Academy of Sciences (2013)
- Keystone Symposium Scholarship, grant from the NIH, Colorado, USA (2012)
- Prize of Excellence for the research activities conducted as undergrad student, UCL, Belgium (2008)
- “Pharmacist & Doctor Nedeljkovitch” Award, Belgian Society of Pharmaceutical Sciences, Belgium (2008)
PROJECT FUNDINGS
PRIZES & AWARDS
PROFESSIONAL EXPERIENCE
Professor in Metabolomics (UCL), Louvain Drug Research Institute. August 2016 – ongoing. “Harnessing the therapeutic potential of the gut microbiota for cancer and cachexia: beyond the usual suspects”
FNRS Post-doctoral Researcher (UCL), Louvain Drug Research Institute, with Prof Nathalie Delzenne. July 2014 – August 2016. “Gut microbiota as a causative factor for cancer-related cachexia: involvement of the gut barrier function”
Post-doctoral Research Associate (University of Nebraska-Lincoln, NE, USA) in the Mucosal Immunology Lab, Prof Amanda Ramer-Tait and in the Gastrointestinal Microbiology Lab, Prof Jens Walter. July 2013 – June 2014. “Role of the gut microbiota in the metabolic improvements induced by resistant starches in obese mice”
Post-doctoral Researcher (UCL), Louvain Drug Research Institute, with Prof Nathalie Delzenne. April 2013 - June 2013. Walloon Region-funded project (NutriGUTior) dedicated to the investigation of nutritional compounds to improve intestinal health in the elderly
FNRS fellow (UCL), Louvain Drug Research Institute, with Prof Nathalie Delzenne. October 2008 - March 2013. “Gut-immunity relationship in the control of cachexia associated with tumour development: role of the gut microbiota.”
EDUCATION
- 15.071x The Analytics Edge (MITx-edX) (90h). A course for multivariate and logistic analyses of large datasets organized by the Massachusetts Institute of Technology, Massachusetts, MA, USA. February – May 2015.
- European Nutrition Leadership Program (ENLP). April 2015.
- Intercultural Leadership skills workshop for postdocs supported by Prins Filip Fonds. September 2014.
- Perl Programming for Biological Applications (UNL, 3 credits, 75h). September-December 2013.
- Intensive one-week workshop: “Next-generation sequencing technologies and bioinformatics analyses” with Dr Ines Martinez, University of Nebraska-Lincoln, NE, USA. August 2013.
- PhD in Biomedical and Pharmaceutical Sciences (UCL). Role of gut microbiota modulation in the control of cancer progression and associated cachexia. Thesis director: Prof. Nathalie Delzenne, Université catholique de Louvain (UCL), Belgium. Mars 2013.
- First Nutrimetabonomics Workshop (University of Reading, UK). April 2012.
- Master in Animal Experimentation (UCL). June 2009.
- Pharmacist (UCL). June 2008.
- Diploma
Year Label Educational Organization 2008 Pharmacienne Université catholique de Louvain 2013 Docteur en sciences biomédicales et pharmaceutiques Université catholique de Louvain
- Courses
Name ID Computerized workshop and research on scientific information related to drugs. WFARM1239 Pharmaceutical genetics and biotechnology WFARM1383 Processus de découverte, de développement et de mise sur le marché du médicament WFARM2128 Pharmacocinetic, genomics and toxicology WFARM2139 Analysis of biotechnology drugs WFARM2266 Introduction to analytical toxicology WFARM2502 Drug dependence and addiction WFARM2514 Nutrition and environment: biological and toxicological aspects WSBIM2137 Nutrition and environment: societal aspects WSBIM2237 Special issues in cancerology WSBIM2244 In-session seminar in biomedicine WSBIM2245
The gut microbiota consists of the trillions of microbes that reside in the gastrointestinal tract of mammals, and has a vast impact on host physiology and metabolism. My research program is dedicated to the investigation of the role and therapeutic potential of the gut microbiota in the progression of non-gastrointestinal cancers and associated cachexia. Cancer cachexia refers to the metabolic alterations linked to cancer progression. Cachexia leads to patient weight loss; it affects up to 50% of cancer patients, causing mortality in 20% of them. Studying the gut microbiota as a therapeutic target constitutes an innovative approach to this pathology, an approach currently followed by my newly established team (currently composed of one graduate student, one postdoctoral fellow and myself).
Want more information? Have a look at this talk I gave on our research at the Oslo Cancer Cluster in January 2018 and do not hesitate to contact me.
2025
Thibaut, Morgane ; Roumain, Martin ; Piron, Edwige ; Gillard, Justine ; Loriot, Axelle ; Neyrinck, Audrey M. ; Rodriguez, Julie ; Massart, Isabelle ; Thissen, Jean-Paul ; Huot, Joshua R ; Pin, Fabrizio ; Bonetto, Andrea ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Bindels, Laure B.. The microbiota-derived bile acid taurodeoxycholic acid improves hepatic cholesterol levels in mice with cancer cachexia.. In: Gut microbes, Vol. 17, no.1, p. 2449586 [1-26] (2025). doi:10.1080/19490976.2025.2449586.
2024
Gillard, Justine ; Roumain, Martin ; Picalausa, Corinne ; Thibaut, Morgane ; Clerbaux, Laure-Alix ; Tailleux, Anne ; Staels, Bart ; Muccioli, Giulio ; Bindels, Laure B. ; Leclercq, Isabelle. A gut microbiota-independent mechanism shapes the bile acid pool in mice with MASH. In: JHEP Reports, Vol. 6, no. 11, p. 101148 [1-11] (2024). doi:10.1016/j.jhepr.2024.101148 (Accepté/Sous presse).
2024
Massart, Isabelle ; Kouakou, Axell-natalie ; Pelet, Nathan ; Lause, Pascale ; Schakman, Olivier ; Loumaye, Audrey ; Abou Samra, Michel ; Deldicque, Louise ; Bindels, Laure B. ; Brichard, Sonia ; Thissen, Jean-Paul. Administration of adiponectin receptor agonist AdipoRon relieves cancer cachexia by mitigating inflammation in tumour-bearing mice.. In: Journal of cachexia, sarcopenia and muscle, , p. [1-15] (2024). doi:10.1002/jcsm.13454 (Accepté/Sous presse).
2024
Pötgens, Sarah ; Havelange, Violaine ; Lecop, Sophie ; Li, Fuyong ; Neyrinck, Audrey M. ; Bindels, Florence ; Neveux, Nathalie ; Demoulin, Jean-Baptiste ; Moors, Ine ; Kerre, Tessa ; Maertens, Johan ; Walter, Jens ; Schoemans, Hélène ; Delzenne, Nathalie M. ; Bindels, Laure B.. Gut microbiome alterations at acute myeloid leukemia diagnosis are associated with muscle weakness and anorexia.. In: Haematologica, (2024). doi:10.3324/haematol.2023.284138 (Accepté/Sous presse).
2024
Muñoz-Fernandez, Shirley S. ; Garcez, Flavia B. ; Alencar, Julio C.G. ; Bastos, Amália A. ; Morley, John E. ; Cederholm, Tommy ; Aprahamian, Ivan ; de Souza, Heraldo P. ; Avelino-Silva, Thiago J. ; Bindels, Laure B. ; Ribeiro, Sandra M.L.. Gut microbiota disturbances in hospitalized older adults with malnutrition and clinical outcomes.. In: Nutrition, , p. 112369 (2024). doi:10.1016/j.nut.2024.112369 (Accepté/Sous presse).
2024
Moens de Hase, Emilie ; Neyrinck, Audrey M. ; Rodriguez, Julie ; Cnop, Miriam ; Paquot, Nicolas ; Thissen, Jean-Paul ; Xu, Yining ; Beloqui Garcia, Ana ; Bindels, Laure B. ; Delzenne, Nathalie M. ; Van Hul, Matthias ; Cani, Patrice D.. Impact of metformin and Dysosmobacter welbionis on diet-induced obesity and diabetes: from clinical observation to preclinical intervention.. In: Diabetologia, Vol. 67, no. 2, p. 333-345 (2024). doi:10.1007/s00125-023-06032-0.
2024
Van Hul, Matthias ; Neyrinck, Audrey M. ; Everard, Amandine ; Abot, Anne ; Bindels, Laure B. ; Delzenne, Nathalie M. ; Knauf, Claude ; Cani, Patrice D.. Role of the intestinal microbiota in contributing to weight disorders and associated comorbidities.. In: Clinical microbiology reviews, , p. e0004523 (2024). doi:10.1128/cmr.00045-23.
2024
Simonson, Mathilde ; Cueff, Gwendal ; Thibaut, Morgane ; Giraudet, Christophe ; Salles, Jérôme ; Chambon, Christophe ; Boirie, Yves ; Bindels, Laure B. ; Gueugneau, Marine ; Guillet, Christelle. Skeletal Muscle Proteome Modifications following Antibiotic-Induced Microbial Disturbances in Cancer Cachexia.. In: Journal of proteome research, Vol. 23, no.7, p. 2452-2473 (2024). doi:10.1021/acs.jproteome.4c00143.
2024
Degraeve, Alexandra ; Bindels, Laure B. ; Haufroid, Vincent ; Moudio Ebosse Timba, Moussinga Serge ; Boland, Lidvine ; Delongie, Kévin-Alexandre ; Dewulf, Joseph P. ; Chaib Eddour, Djamila ; Mourad, Michel ; Elens, Laure. Tacrolimus pharmacokinetics is associated with gut microbiota diversity in kidney transplant patients: results from a pilot cross‐sectional study. In: Clinical pharmacology and therapeutics, Vol. 115, no. 1, p. 104-115 (2024). doi:10.1002/cpt.3077.
2024
Delzenne, Nathalie M. ; Bindels, Laure B. ; Neyrinck, Audrey M. ; Walter, Jens. The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer.. In: Nature reviews. Microbiology, , p. [1-14] (2024). doi:10.1038/s41579-024-01108-z (Accepté/Sous presse).
2024
Berger, Mette M ; Amrein, Karin ; Barazzoni, Rocco ; Bindels, Laure B. ; Bretón, Irene ; Calder, Philip C ; Cappa, Stefano ; Cuerda, Cristina ; D'Amelio, Patrizia ; de Man, Angélique ; Delzenne, Nathalie M. ; Forbes, Alastair ; Genton, Laurence ; Gombart, Adrian F ; Joly, Francisca ; Laviano, Alessandro ; Matthys, Christophe ; Phyo, Pyi Pyi ; Ravasco, Paula ; Serlie, Mireille J ; Shenkin, Alan ; Stoffel, Nicole U ; Talwar, Dinesh ; van Zanten, Arthur R H. The science of micronutrients in clinical practice - Report on the ESPEN symposium.. In: Clinical nutrition, Vol. 43, no.1, p. 268-283 (2024). doi:10.1016/j.clnu.2023.12.006.
2024
Lefevre, Camille ; Thibaut, Morgane ; Loumaye, Audrey ; Thissen, Jean-Paul ; Neyrinck, Audrey M. ; Navez, Benoît ; Delzenne, Nathalie M. ; Feron, Olivier ; Bindels, Laure B.. Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis.. In: Molecular metabolism, Vol. 83, p. 101930 [1-18] (2024). doi:10.1016/j.molmet.2024.101930.
2023
Cremer, Julie ; Brohée, Laura ; Dupont, Laura ; Lefevre, Camille ; Peiffer, Raphaël ; Saarinen, Alicia M ; Peulen, Olivier ; Bindels, Laure B. ; Liu, Jun ; Colige, Alain ; Deroanne, Christophe F. Acidosis-induced regulation of adipocyte G0S2 promotes crosstalk between adipocytes and breast cancer cells as well as tumor progression.. In: Cancer letters, Vol. 569, p. 216306 [1-13] (2023). doi:10.1016/j.canlet.2023.216306.
2023
Degraeve, Alexandra ; Haufroid, Vincent ; Loriot, Axelle ; Gatto, Laurent ; Andries, Vanessa ; Vereecke, Lars ; Elens, Laure ; Bindels, Laure B.. Gut microbiome modulates tacrolimus pharmacokinetics through the transcriptional regulation of ABCB1. In: Microbiome, Vol. 11, no. 1, p. 138 [1-20] (2023). doi:10.1186/s40168-023-01578-y.
2023
Pötgens, Sarah ; Lecop, Sophie (co-first author) ; Havelange, Violaine ; Li, Fuyong ; Neyrinck, Audrey M. ; Neveux, Nathalie ; Maertens, Johan ; Walter, Jens ; Schoemans, Hélène ; Delzenne, Nathalie M. ; Bindels, Laure B.. Gut microbiota alterations induced by intensive chemotherapy in acute myeloid leukaemia patients are associated with gut barrier dysfunction and body weight loss.. In: Clinical nutrition, Vol. 42, no.11, p. 2214-2228 (2023). doi:10.1016/j.clnu.2023.09.021.
2023
Dolly, Adeline ; Pötgens, Sarah ; Thibaut, Morgane ; Neyrinck, Audrey M. ; de Castro, Gabriela S ; Galbert, Chloé ; Lefevre, Camille ; Wyart, Elisabeth ; Gomes, Silvio P ; Gonçalves, Daniela C ; Lanthier, Nicolas ; Baldin, Paméla ; Huot, Joshua R ; Bonetto, Andrea ; Seelaender, Marília ; Delzenne, Nathalie M. ; Sokol, Harry ; Bindels, Laure B.. Impairment of aryl hydrocarbon receptor signalling promotes hepatic disorders in cancer cachexia.. In: Journal of cachexia, sarcopenia and muscle, Vol. 14, no. 3, p. 1569-1582 (2023). doi:10.1002/jcsm.13246.
2023
Bilson, Josh ; Oquendo, Carolina J ; Read, James ; Scorletti, Eleonora ; Afolabi, Paul R ; Lord, Jenny ; Bindels, Laure B. ; Targher, Giovanni ; Mahajan, Sumeet ; Baralle, Diana ; Calder, Philip C ; Byrne, Christopher D ; Sethi, Jaswinder K. Markers of adipose tissue fibrogenesis associate with clinically significant liver fibrosis and are unchanged by synbiotic treatment in patients with NAFLD.. In: Metabolism: clinical and experimental, Vol. 151, p. 155759 [1-12] (2023). doi:10.1016/j.metabol.2023.155759.
2023
Zubiaga, Lorea ; Briand, Olivier ; Auger, Florent ; Touche, Veronique ; Hubert, Thomas ; Thevenet, Julien ; Marciniak, Camille ; Quenon, Audrey ; Bonner, Caroline ; Peschard, Simon ; Raverdy, Violeta ; Daoudi, Mehdi ; Kerr-Conte, Julie ; Pasquetti, Gianni ; Koepsell, Hermann ; Zdzieblo, Daniela ; Mühlemann, Markus ; Thorens, Bernard ; Delzenne, Nathalie M. ; Bindels, Laure B. ; Deprez, Benoit ; Vantyghem, Marie C ; Laferrère, Blandine ; Staels, Bart ; Huglo, Damien ; Lestavel, Sophie ; Pattou, François. Oral metformin transiently lowers post-prandial glucose response by reducing the apical expression of sodium-glucose co-transporter 1 in enterocytes.. In: iScience, Vol. 26, no.4, p. 106057 [1-17] (2023). doi:10.1016/j.isci.2023.106057.
2023
Mbusa Kambale, Richard ; Ntagazibwa, Joseph Ntagerwa ; Kasengi, Joe Bwija ; Zigashane, Adrien Burume ; Francisca, Isia Nancy ; Mashukano, Benjamin Ntaligeza ; Amani Ngaboyeka, Gaylord ; Bahizire, Esto ; Zech, Francis ; Bindels, Laure B. ; Van der Linden, Dimitri. Probiotics for children with uncomplicated severe acute malnutrition (PruSAM study): A randomized controlled trial in the Democratic Republic of Congo.. In: The American journal of clinical nutrition, Vol. 117, no. 5, p. 976-984 (2023). doi:10.1016/j.ajcnut.2023.01.019.
2023
Falascina, Gianna ; Bindels, Laure B. ; Di Marzo, Vincenzo ; Cutignano, Adele. Validation of a fast and sensitive UPLC-MS/MS quantitative method for N-acyl taurine analysis in biological samples.. In: Journal of pharmaceutical and biomedical analysis, Vol. 226, p. 115252 [1-8] (2023). doi:10.1016/j.jpba.2023.115252.
2022
Loumaye, Audrey ; Lause, Pascale ; Zhong, Xiaoling ; Zimmers, Teresa A ; Bindels, Laure B. ; Thissen, Jean-Paul. Activin A Causes Muscle Atrophy through MEF2C-Dependent Impaired Myogenesis.. In: Cells, Vol. 11, no. 7, p. 1119 [1-18] (2022). doi:10.3390/cells11071119.
2022
Gillard, Justine ; Clerbaux, Laure-Alix ; Nachit, Maxime Younes ; Sempoux, Christine ; Staels, Bart ; Bindels, Laure B. ; Tailleux, Anne ; Leclercq, Isabelle. Bile acids contribute to the development of non-alcoholic steatohepatitis in mice.. In: JHEP reports, Vol. 4, no. 1, p. 100387 [1-13] (2022). doi:10.1016/j.jhepr.2021.100387.
2022
Neyrinck, Audrey M. ; Rodriguez, Julie ; Zhang, Zhengxiao ; Nazare, Julie-Anne ; Bindels, Laure B. ; Cani, Patrice D. ; Maquet, Véronique ; Laville, Martine ; Bischoff, Stephan C ; Walter, Jens ; Delzenne, Nathalie M.. Breath volatile metabolome reveals the impact of dietary fibres on the gut microbiota: Proof of concept in healthy volunteers.. In: EBioMedicine, Vol. 80, p. 104051 [1-13] (2022). doi:10.1016/j.ebiom.2022.104051.
2022
Neyrinck, Audrey M. ; Rodriguez, Julie ; Taminiau, Bernard ; Herpin, Florent ; Cani, Patrice D. ; Daube, Georges ; Bindels, Laure B. ; Delzenne, Nathalie M.. Constipation Mitigation by Rhubarb Extract in Middle-Aged Adults Is Linked to Gut Microbiome Modulation: A Double-Blind Randomized Placebo-Controlled Trial.. In: International journal of molecular sciences, Vol. 23, no.23, p. 14685 [1-15] (2022). doi:10.3390/ijms232314685.
2022
Thibaut, Morgane ; Bindels, Laure B.. Crosstalk between bile acid-activated receptors and microbiome in entero-hepatic inflammation. In: Trends in Molecular Medicine, Vol. 28, no. 3, p. 223-236 (2022). doi:10.1016/j.molmed.2021.12.006.
2022
Le Roy, Tiphaine ; Moens De Hase, Emilie ; Van Hul, Matthias ; Paquot, Adrien ; Pelicaen, Rudy ; Régnier, Marion ; Depommier, Clara ; Druart, Céline ; Everard, Amandine ; Maiter, Dominique ; Delzenne, Nathalie M. ; Bindels, Laure B. ; de Barsy, Marie ; Loumaye, Audrey ; Hermans, Michel ; Thissen, Jean-Paul ; Vieira-Silva, Sara ; Falony, Gwen ; Raes, Jeroen ; Muccioli, Giulio ; Cani, Patrice D.. Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice. In: Gut, Vol. 71, p. 534–543 (2022). doi:10.1136/gutjnl-2020-323778.
2022
Aron-Wisnewsky, Judith ; Lefevre, Camille ; Bindels, Laure B.. Interactions entre les traitements du diabète et le microbiote intestinal : état des connaissances et perspectives. In: Médecine des maladies métaboliques, Vol. 16, no.2, p. 148-159 (2022). doi:10.1016/j.mmm.2022.01.004.
2022
Wyart, Elisabeth ; Hsu, Myriam Y ; Sartori, Roberta ; Mina, Erica ; Rausch, Valentina ; Pierobon, Elisa S ; Mezzanotte, Mariarosa ; Pezzini, Camilla ; Bindels, Laure B. ; Lauria, Andrea ; Penna, Fabio ; Hirsch, Emilio ; Martini, Miriam ; Mazzone, Massimiliano ; Roetto, Antonella ; Geninatti Crich, Simonetta ; Prenen, Hans ; Sandri, Marco ; Menga, Alessio ; Porporato, Paolo E. Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia.. In: EMBO reports, Vol. 23, no. 4, p. e53746 [1-18] (2022). doi:10.15252/embr.202153746.
2022
Leyrolle, Quentin ; Cserjesi, Renata ; Demeure, Romane ; Neyrinck, Audrey M. ; Amadieu, Camille ; Rodriguez, Julie ; Kärkkäinen, Olli ; Hanhineva, Kati ; Paquot, Nicolas ; Cnop, Miriam ; Cani, Patrice D. ; Thissen, Jean-Paul ; Bindels, Laure B. ; Klein, Olivier ; Luminet, Olivier ; Delzenne, Nathalie M.. Microbiota and Metabolite Profiling as Markers of Mood Disorders: A Cross-Sectional Study in Obese Patients.. In: Nutrients, Vol. 14, no. 1, p. 147- (2022). doi:10.3390/nu14010147.
2022
Rodriguez, Julie ; Neyrinck, Audrey M. ; Van Kerckhoven, Maxime ; Gianfrancesco, Marco A ; Renguet, Edith ; Bertrand, Luc ; Cani, Patrice D. ; Lanthier, Nicolas ; Cnop, Miriam ; Paquot, Nicolas ; Thissen, Jean-Paul ; Bindels, Laure B. ; Delzenne, Nathalie M.. Physical activity enhances the improvement of body mass index and metabolism by inulin: a multicenter randomized placebo-controlled trial performed in obese individuals.. In: BMC medicine, Vol. 20, no.1, p. 110 [1-20] (2022). doi:10.1186/s12916-022-02299-z.
2022
Amadieu, Camille ; Coste, Valentin ; Neyrinck, Audrey M. ; Thijssen, Victoria ; Leyrolle, Quentin ; Bindels, Laure B. ; Piessevaux, Hubert ; Starkel, Peter ; de Timary, Philippe ; Delzenne, Nathalie M. ; Leclercq, Sophie. Restoring an adequate dietary fiber intake by inulin supplementation: a pilot study showing an impact on gut microbiota and sociability in alcohol use disorder patients. In: Gut Microbes, Vol. 14, no. 1, p. 2007042 [1-20] (2022). doi:10.1080/19490976.2021.2007042.
2022
Lefevre, Camille ; Bindels, Laure B.. Role of the Gut Microbiome in Skeletal Muscle Physiology and Pathophysiology.. In: Current osteoporosis reports, Vol. 20, no. 6, p. 422-432 (2022). doi:10.1007/s11914-022-00752-9.
2021
Nachit, Maxime Younes ; Lanthier, Nicolas ; Rodriguez, Julie ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Bindels, Laure B. ; Hiel, Sophie ; Pachikian, Barbara D. ; Trefois, Pierre ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. A dynamic association between myosteatosis and liver stiffness: Results from a prospective interventional study in obese patients. In: JHEP Reports, Vol. 3, no. 4, p. 100323 [1-10] (2021). doi:10.1016/j.jhepr.2021.100323.
2021
Thibaut, Morgane ; Gillard, Justine ; Dolly, Adeline ; Roumain, Martin ; Leclercq, Isabelle ; Delzenne, Nathalie M. ; Muccioli, Giulio ; Bindels, Laure B.. Bile Acid Dysregulation Is Intrinsically Related to Cachexia in Tumor-Bearing Mice. In: Cancers, Vol. 13, no.24, p. 6389 [1-17] (2021). doi:10.3390/cancers13246389.
2021
Amadieu, Camille ; Leclercq, Sophie ; Coste, Valentin ; Thijssen, Victoria ; Neyrinck, Audrey M. ; Bindels, Laure B. ; Cani, Patrice D. ; Piessevaux, Hubert ; Starkel, Peter ; De Timary, Philippe ; Delzenne, Nathalie M.. Dietary fiber deficiency as a component of malnutrition associated with psychological alterations in alcohol use disorder.. In: Clinical nutrition, Vol. 40, no. 5, p. 2673-2682 (2021). doi:10.1016/j.clnu.2021.03.029.
2021
Mbusa Kambale, Richard ; Nancy, Fransisca Isia ; Ngaboyeka, Gaylord Amani ; Kasengi, Joe Bwija ; Bindels, Laure B. ; Van der Linden, Dimitri. Effects of probiotics and synbiotics on diarrhea in undernourished children: Systematic review with meta-analysis. In: Clinical Nutrition, Vol. 40, no. 5, p. 3158-3169 (2021). doi:10.1016/j.clnu.2020.12.026.
2021
Bilson, Josh ; Scorletti, Eleonora ; Bindels, Laure B. ; Afolabi, Paul R ; Targher, Giovanni ; Calder, Philip C ; Sethi, Jaswinder K ; Byrne, Christopher D. Growth differentiation factor-15 and the association between type 2 diabetes and liver fibrosis in NAFLD.. In: Nutrition & diabetes, Vol. 11, no.1, p. 32 [1-9] (2021). doi:10.1038/s41387-021-00170-3.
2021
Breton, Jonathan ; Tirelle, Pauline ; Hasanat, Soujoud ; Pernot, Arthur ; L'Huillier, Clément ; do Rego, Jean-Claude ; Déchelotte, Pierre ; Coëffier, Moïse ; Bindels, Laure B. ; Ribet, David. Gut microbiota alteration in a mouse model of Anorexia Nervosa.. In: Clinical Nutrition, Vol. 40, no. 1, p. 181-189 (2021). doi:10.1016/j.clnu.2020.05.002.
2021
Knudsen, Christelle ; Neyrinck, Audrey M. ; Leyrolle, Quentin ; Baldin, Paméla ; Leclercq, Sophie ; Rodriguez, Julie ; Beaumont, Martin ; Cani, Patrice D. ; Bindels, Laure B. ; Lanthier, Nicolas ; Delzenne, Nathalie M.. Hepatoprotective Effects of Indole, a Gut Microbial Metabolite, in Leptin-Deficient Obese Mice.. In: The Journal of nutrition, Vol. 151, no. 6, p. 1507-1516 (2021). doi:10.1093/jn/nxab032.
2021
Neyrinck, Audrey M. ; Rodriguez, Julie ; Taminiau, Bernard ; Amadieu, Camille ; Herpin, Florent ; Allaert, François-André ; Cani, Patrice D. ; Daube, Georges ; Bindels, Laure B. ; Delzenne, Nathalie M.. Improvement of gastrointestinal discomfort and inflammatory status by a synbiotic in middle-aged adults: a double-blind randomized placebo-controlled trial.. In: Scientific reports, Vol. 11, no.1, p. 2627 [1-12] (2021). doi:10.1038/s41598-020-80947-1.
2021
Thibaut, Morgane ; Sboarina, Martina ; Roumain, Martin ; Pötgens, Sarah ; Neyrinck, Audrey M. ; Destrée, Florence ; Gillard, Justine ; Leclercq, Isabelle ; Dachy, Guillaume ; Demoulin, Jean-Baptiste ; Tailleux, Anne ; Lestavel, Sophie ; Rastelli, Marialetizia ; Everard, Amandine ; Cani, Patrice D. ; Porporato, Paolo E ; Loumaye, Audrey ; Thissen, Jean-Paul ; Muccioli, Giulio ; Delzenne, Nathalie M. ; Bindels, Laure B.. Inflammation-induced cholestasis in cancer cachexia.. In: Journal of cachexia, sarcopenia and muscle, Vol. 12, no. 1, p. 70-20 (2021). doi:10.1002/jcsm.12652.
2021
Lanthier, Nicolas ; Rodriguez, Julie ; Nachit, Maxime Younes ; Hiel, Sophie ; Trefois, Pierre ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Bindels, Laure B. ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Microbiota analysis and transient elastography reveal new extra-hepatic components of liver steatosis and fibrosis in obese patients.. In: Scientific reports, Vol. 11, no. 1, p. 659 [1-14] (2021). doi:10.1038/s41598-020-79718-9.
2021
Pötgens, Sarah ; Thibaut, Morgane ; Joudiou, Nicolas ; Sboarina, Martina ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Claus, Sandrine P ; Delzenne, Nathalie M. ; Bindels, Laure B.. Multi-compartment metabolomics and metagenomics reveal major hepatic and intestinal disturbances in cancer cachectic mice.. In: Journal of cachexia, sarcopenia and muscle, , p. [1-20] (2021). doi:10.1002/jcsm.12684 (Accepté/Sous presse).
2021
Neyrinck, Audrey M. ; Rodriguez, Julie ; Zhang, Zhengxiao ; Seethaler, Benjamin ; Mailleux, Florence ; Vercammen, Joeri ; Bindels, Laure B. ; Cani, Patrice D. ; Nazare, Julie-Anne ; Maquet, Véronique ; Laville, Martine ; Bischoff, Stephan C ; Walter, Jens ; Delzenne, Nathalie M.. Noninvasive monitoring of fibre fermentation in healthy volunteers by analyzing breath volatile metabolites: lessons from the FiberTAG intervention study.. In: Gut microbes, Vol. 13, no.1, p. e1862028 [1-16] (2021). doi:10.1080/19490976.2020.1862028.
2021
Neyrinck, Audrey M. ; Robles Sanchez, Candido ; Rodriguez, Julie ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Prebiotic Effect of Berberine and Curcumin Is Associated with the Improvement of Obesity in Mice. In: Nutrients, Vol. 13, no.5, p. 1436 [1-13] (2021). doi:10.3390/nu13051436.
2021
Neyrinck, Audrey M. ; Rodriguez, Julie (co-first author) ; Zhang, Zhengxiao ; Seethaler, Benjamin ; Robles Sanchez, Candido ; Roumain, Martin ; Hiel, Sophie ; Bindels, Laure B. ; Cani, Patrice D. ; Paquot, Nicolas ; Cnop, Miriam ; Nazare, Julie-Anne ; Laville, Martine ; Muccioli, Giulio ; Bischoff, Stephan C ; Walter, Jens ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Prebiotic dietary fibre intervention improves fecal markers related to inflammation in obese patients: results from the Food4Gut randomized placebo-controlled trial.. In: European journal of nutrition, Vol. 60, no. 6, p. 3159-3170 (2021). doi:10.1007/s00394-021-02484-5 (Accepté/Sous presse).
2021
Leyrolle, Quentin ; Cserjesi, Renata ; D.G.H. Mulders, Maria ; Zamariola, Giorgia ; Hiel, Sophie ; Gianfrancesco, Marco A. ; Portheault, Daphné ; Amadieu, Camille ; Bindels, Laure B. ; Leclercq, Sophie ; Rodriguez, Julie ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Lanthier, Nicolas ; Trefois, Pierre ; Bindelle, Jérome ; Paquot, Nicolas ; Cnop, Miriam ; Thissen, Jean-Paul ; Klein, Olivier ; Luminet, Olivier ; Delzenne, Nathalie M.. Prebiotic effect on mood in obese patients is determined by the initial gut microbiota composition: a randomized, controlled trial. In: Brain, Behavior, and Immunity, Vol. 94, no. May, p. 289-298 (2021). doi:10.1016/j.bbi.2021.01.014.
2021
Lanthier, Nicolas ; Rodriguez, Julie ; Nachit, Maxime Younes ; Hiel, Sophie ; Trefois, Pierre ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Bindels, Laure B. ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Publisher Correction: Microbiota analysis and transient elastography reveal new extra-hepatic components of liver steatosis and fibrosis in obese patients.. In: Scientific reports, Vol. 11, no.1, p. 6123 (2021). doi:10.1038/s41598-021-85083-y.
2021
Leyrolle, Quentin ; Cserjesi, Renata ; Mulders, Maria D G H ; Zamariola, Giorgia ; Hiel, Sophie ; Gianfrancesco, Marco A ; Rodriguez, Julie ; Portheault, Daphnée ; Amadieu, Camille ; Leclercq, Sophie ; Bindels, Laure B. ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Karkkainen, Olli ; Haninheva, Kati ; Lanthier, Nicolas ; Trefois, Pierre ; Paquot, Nicolas ; Cnop, Miriam ; Thissen, Jean-Paul ; Klein, Olivier ; Luminet, Olivier ; Delzenne, Nathalie M.. Specific gut microbial, biological, and psychiatric profiling related to binge eating disorders: A cross-sectional study in obese patients.. In: Clinical nutrition (Edinburgh, Scotland), Vol. 40, p. 2035-2044 (2021). doi:10.1016/j.clnu.2020.09.025.
2021
La, Caroline ; de Toeuf, Bérengère ; Bindels, Laure B. ; Van Maele, Laurye ; Assabban, Assiya ; Melchior, Maxime ; Smout, Justine ; Köhler, Arnaud ; Nguyen, Muriel ; Thomas, Séverine ; Soin, Romuald ; Delacourt, Nadège ; Li, Hsüehlei ; Hu, Wenqian ; Blackshear, Perry J ; Kruys, Véronique ; Gueydan, Cyril ; Oldenhove, Guillaume ; Goriely, Stanislas. The RNA-binding protein tristetraprolin regulates RALDH2 expression by intestinal dendritic cells and controls local Treg homeostasis.. In: Mucosal immunology, Vol. 14, no. 11, p. 80-91 (2021). doi:10.1038/s41385-020-0302-x.
2020
Wyart, Elisabeth ; Bindels, Laure B. ; Mina, Erica ; Menga, Alessio ; Stanga, Serena ; Porporato, Paolo E. Cachexia, a Systemic Disease beyond Muscle Atrophy.. In: International journal of molecular sciences, Vol. 21, no.22, p. 8592 [1-18] (2020). doi:10.3390/ijms21228592.
2020
Rodriguez, Julie ; Hiel, Sophie ; Neyrinck, Audrey M. ; Le Roy, Tiphaine ; Pötgens, Sarah ; Leyrolle, Quentin ; Pachikian, Barbara D. ; Gianfrancesco, Marco A ; Cani, Patrice D. ; Paquot, Nicolas ; Cnop, Miriam ; Lanthier, Nicolas ; Thissen, Jean-Paul ; Bindels, Laure B. ; Delzenne, Nathalie M.. Discovery of the gut microbial signature driving the efficacy of prebiotic intervention in obese patients.. In: Gut, Vol. 69, no. 11, p. 1975-1987 (2020). doi:10.1136/gutjnl-2019-319726.
2020
Delzenne, Nathalie M. ; Bindels, Laure B.. Food for thought about manipulating gut bacteria. In: Nature, Vol. 577, no. 7788, p. 32-34 (2020). doi:10.1038/d41586-019-03704-z.
2020
Leclercq, Sophie ; Le Roy, Tiphaine ; Furgiuele, Sonia ; Coste, Valentin ; Bindels, Laure B. ; Leyrolle, Quentin ; Neyrinck, Audrey M. ; Quoilin, Caroline ; Amadieu, Camille ; Petit, Géraldine ; Dricot, Laurence ; Tagliatti, Vanessa ; Cani, Patrice D. ; Verbeke, Kristin ; Colet, Jean-Marie ; Starkel, Peter ; de Timary, Philippe ; Delzenne, Nathalie M.. Gut Microbiota-Induced Changes in β-Hydroxybutyrate Metabolism Are Linked to Altered Sociability and Depression in Alcohol Use Disorder.. In: Cell reports, Vol. 33, no.2, p. 108238 [1-24] (2020). doi:10.1016/j.celrep.2020.108238.
2020
Hiel, Sophie ; Gianfrancesco, Marco A. ; Rodriguez, Julie ; Portheault, Daphnée ; Leyrolle, Quentin ; Bindels, Laure B. ; Gomes da Silveira Cauduro, Carolina ; Mulders, Maria D.G.H. ; Zamariola, Georgia ; Azzi, Anne-Sophie ; Kalala, Gaetan ; Pachikian, Barbara D. ; Amadieu, Camille ; Neyrinck, Audrey M. ; Loumaye, Audrey ; Cani, Patrice D. ; Lanthier, Nicolas ; Trefois, Pierre ; Klein, Olivier ; Luminet, Olivier ; Bindelle, Jérôme ; Paquot, Nicolas ; Cnop, Miriam ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Link between gut microbiota and health outcomes in inulin -treated obese patients: Lessons from the Food4Gut multicenter randomized placebo-controlled trial. In: Clinical Nutrition, Vol. 39, no. 12, p. 3618-3628 (2020). doi:10.1016/j.clnu.2020.04.005.
2020
Massart, Isabelle ; Paulissen, Geneviève ; Loumaye, Audrey ; Lause, Pascale ; Pötgens, Sarah ; Thibaut, Morgane ; Balan, Estelle ; Deldicque, Louise ; Atfi, Azeddine ; Louis, Edouard ; Gruson, Damien ; Bindels, Laure B. ; Meuwis, Marie-Alice ; Thissen, Jean-Paul. Marked Increased Production of Acute Phase Reactants by Skeletal Muscle during Cancer Cachexia. In: Cancers, Vol. 12, no.11, p. 3221 [1-24] (2020). doi:10.3390/cancers12113221.
2020
Rodriguez, Julie ; Neyrinck, Audrey M. ; Zhang, Zhengxiao ; Seethaler, Benjamin ; Nazare, Julie-Anne ; Robles Sanchez, Candido ; Roumain, Martin ; Muccioli, Giulio ; Bindels, Laure B. ; Cani, Patrice D. ; Maquet, Véronique ; Laville, Martine ; Bischoff, Stephan C ; Walter, Jens ; Delzenne, Nathalie M.. Metabolite profiling reveals the interaction of chitin-glucan with the gut microbiota.. In: Gut microbes, Vol. 12, no. 1, p. 1810530 [1-15] (2020). doi:10.1080/19490976.2020.1810530.
2020
Degraeve, Alexandra ; Moudio Ebosse Timba, Moussinga Serge ; Haufroid, Vincent ; Chaib Eddour, Djamila ; Mourad, Michel ; Bindels, Laure B. ; Elens, Laure. Predictors of tacrolimus pharmacokinetic variability: current evidences and future perspectives.. In: Expert Opinion on Drug Metabolism & Toxicology, Vol. 16, no. 9, p. 769-782 (2020). doi:10.1080/17425255.2020.1803277.
2020
Segura Munoz, Rafael R ; Quach, Truyen ; Gomes-Neto, João C ; Xian, Yibo ; Pena, Pamela A ; Weier, Steven ; Pellizzon, Michael A ; Kittana, Hatem ; Cody, Liz A ; Geis, Abby L ; Heck, Kari ; Schmaltz, Robert J ; Bindels, Laure B. ; Cahoon, Edgar B ; Benson, Andrew K ; Clemente, Tom Elmo ; Ramer-Tait, Amanda E. Stearidonic-Enriched Soybean Oil Modulates Obesity, Glucose Metabolism, and Fatty Acid Profiles Independently of Akkermansia muciniphila.. In: Molecular nutrition & food research, Vol. 64, no.17, p. e2000162 [1-10] (2020). doi:10.1002/mnfr.202000162.
2020
Scorletti, Eleonora ; Afolabi, Paul R ; Miles, Elizabeth A ; Smith, Debbie E ; Almehmadi, Amal ; Alshathry, Albandri ; Childs, Caroline E ; Del Fabbro, Stefania ; Beavis, Josh ; Moyses, Helen E ; Clough, Geraldine F ; Sethi, Jaswinder K ; Patel, Janisha ; Wright, Mark ; Breen, David J ; Peebles, Charles ; Darekar, Angela ; Aspinall, Richard ; Fowell, Andrew J ; Dowman, Joanna K ; Nobili, Valerio ; Targher, Giovanni ; Delzenne, Nathalie M. ; Bindels, Laure B. ; Calder, Philip C ; Byrne, Christopher D. Synbiotics Alter Fecal Microbiomes, But Not Liver Fat or Fibrosis, in a Randomized Trial of Patients With Nonalcoholic Fatty Liver Disease. In: Gastroenterology, Vol. 158, no. 6, p. 1597-1610.e7 (2020). doi:10.1053/j.gastro.2020.01.031.
2020
Ducastel, Sarah ; Touche, Véronique ; Trabelsi, Mohamed-Sami ; Boulinguiez, Alexis ; Butruille, Laura ; Nawrot, Margaux ; Peschard, Simon ; Chávez-Talavera, Oscar ; Dorchies, Emilie ; Vallez, Emmanuelle ; Annicotte, Jean-Sébastien ; Lancel, Steve ; Briand, Olivier ; Bantubungi, Kadiombo ; Caron, Sandrine ; Bindels, Laure B. ; Delzenne, Nathalie M. ; Tailleux, Anne ; Staels, Bart ; Lestavel, Sophie. The nuclear receptor FXR inhibits Glucagon-Like Peptide-1 secretion in response to microbiota-derived Short-Chain Fatty Acids.. In: Scientific reports, Vol. 10, no.1, p. 174 [1-10] (2020). doi:10.1038/s41598-019-56743-x.
2019
Bernard, Arnaud ; Ancel, Déborah ; Neyrinck, Audrey M. ; Dastugue, Aurélie ; Bindels, Laure B. ; Delzenne, Nathalie M. ; Besnard, Philippe. A Preventive Prebiotic Supplementation Improves the Sweet Taste Perception in Diet-Induced Obese Mice.. In: Nutrients, Vol. 11, no.3, p. 549 [1-13] (2019). doi:10.3390/nu11030549.
2019
Neyrinck, Audrey M. ; Catry, Emilie ; Taminiau, Bernard ; Cani, Patrice D. ; Bindels, Laure B. ; Daube, Georges ; Dessy, Chantal ; Delzenne, Nathalie M.. Chitin-glucan and pomegranate polyphenols improve endothelial dysfunction.. In: Scientific Reports, Vol. 9, no.1, p. 14150 [1-12] (2019). doi:10.1038/s41598-019-50700-4.
2019
Delzenne, Nathalie M. ; Knudsen, Christelle ; Beaumont, Martin ; Rodriguez, Julie ; Neyrinck, Audrey M. ; Bindels, Laure B.. Contribution of the gut microbiota to the regulation of host metabolism and energy balance: a focus on the gut-liver axis.. In: The Proceedings of the Nutrition Society, Vol. 78, no. 3, p. 319-328 (2019). doi:10.1017/S0029665118002756.
2019
Hiel, Sophie ; Bindels, Laure B. (co-first author) ; Pachikian, Barbara D. (co-first author) ; Kalala, Gaetan (co-first author) ; Broers, Valérie ; Zamariola, Giorgia ; Chang, Betty PI ; Kambashi, Bienvenu ; Rodriguez, Julie ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Thissen, Jean-Paul ; Luminet, Olivier ; Bindelle, Jérôme ; Delzenne, Nathalie M.. Effects of a diet based on inulin-rich vegetables on gut health and nutritional behavior in healthy humans. In: The American Journal of Clinical Nutrition, Vol. 109, no. 6, p. 1683-1695 (2019). doi:10.1093/ajcn/nqz001.
2019
Salazar, Nuria ; Neyrinck, Audrey M. ; Bindels, Laure B. ; Druart, Céline ; Ruas-Madiedo, Patricia ; Cani, Patrice D. ; de los Reyes-Gavilán, Clara G. ; Delzenne, Nathalie M.. Functional Effects of EPS-Producing Bifidobacterium Administration on Energy Metabolic Alterations of Diet-Induced Obese Mice. In: Frontiers in Microbiology, Vol. 10, p. 1809 [1-12] (2019). doi:10.3389/fmicb.2019.01809.
2019
Biver, Emmanuel ; Berenbaum, Francis ; Valdes, Ana M ; Araujo de Carvalho, Islene ; Bindels, Laure B. ; Brandi, Maria Luisa ; Calder, Philip C ; Castronovo, Vincenzo ; Cavalier, Etienne ; Cherubini, Antonio ; Cooper, Cyrus ; Dennison, Elaine ; Franceschi, Claudio ; Fuggle, Nicholas ; Laslop, Andrea ; Miossec, Pierre ; Thomas, Thierry ; Tuzun, Sansin ; Veronese, Nicola ; Vlaskovska, Mila ; Reginster, Jean-Yves ; Rizzoli, René. Gut microbiota and osteoarthritis management: An expert consensus of the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO).. In: Ageing Research Reviews, Vol. 55, p. 100946 [1-8] (2019). doi:10.1016/j.arr.2019.100946.
2019
Milard, Marine ; Laugerette, Fabienne ; Durand, Annie ; Buisson, Charline ; Meugnier, Emmanuelle ; Loizon, Emmanuelle ; Louche-Pelissier, Corinne ; Sauvinet, Valérie ; Garnier, Lorna ; Viel, Sébastien ; Bertrand, Karène ; Joffre, Florent ; Cheillan, David ; Humbert, Lydie ; Rainteau, Dominique ; Plaisancié, Pascale ; Bindels, Laure B. ; Neyrinck, Audrey M. ; Delzenne, Nathalie M. ; Michalski, Marie-Caroline. Milk Polar Lipids in a High-Fat Diet Can Prevent Body Weight Gain: Modulated Abundance of Gut Bacteria in Relation with Fecal Loss of Specific Fatty Acids.. In: Molecular Nutrition & Food Research, Vol. 63, no. 4, p. e1801078 [1-13] (2019). doi:10.1002/mnfr.201801078.
2019
Genton, Laurence ; Mareschal, Julie ; Charretier, Yannick ; Lazarevic, Vladimir ; Bindels, Laure B. ; Schrenzel, Jacques. Targeting the Gut Microbiota to Treat Cachexia.. In: Frontiers in cellular and infection microbiology, Vol. 9, p. 305 [1-8] (2019). doi:10.3389/fcimb.2019.00305.
2019
Olivares Sevilla, Marta ; Rodriguez, Julie ; Pötgens, Sarah ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. The Janus Face of Cereals: Wheat‐Derived Prebiotics Counteract the Detrimental Effect of Gluten on Metabolic Homeostasis in Mice Fed a High‐Fat/High‐Sucrose Diet. In: Molecular Nutrition & Food Research, Vol. 63, no. 24, p. 1900632 [1-12] (2019). doi:10.1002/mnfr.201900632.
2018
Kittana, Hatem ; Gomes-Neto, João Carlos ; Heck, Kari ; Geis, Abby L. ; Segura Muñoz, Rafael R. ; Cody, Liz A. ; Schmaltz, Robert J. ; Bindels, Laure B. ; Sinha, Rohita ; Hostetter, Jesse M. ; Benson, Andrew K. ; Ramer-Tait, Amanda E.. Commensal Escherichia coli Strains Can Promote Intestinal Inflammation via Differential Interleukin-6 Production. In: Frontiers in Immunology, Vol. 9, p. 2318 [1-13] (2018). doi:10.3389/fimmu.2018.02318.
2018
Scorletti, Eleonora ; Afolabi, Paul R ; Miles, Elizabeth A ; Smith, Debbie E ; Almehmadi, Amal ; Alshathry, Albandri ; Moyses, Helen E ; Clough, Geraldine F ; Wright, Mark ; Patel, Janisha ; Bindels, Laure B. ; Delzenne, Nathalie M. ; Calder, Philip C ; Byrne, Christopher D. Design and rationale of the INSYTE study: A randomised, placebo controlled study to test the efficacy of a synbiotic on liver fat, disease biomarkers and intestinal microbiota in non-alcoholic fatty liver disease.. In: Contemporary Clinical Trials, Vol. 71, p. 113-123 (2018). doi:10.1016/j.cct.2018.05.010.
2018
Kittana, Hatem ; Quintero-Villegas, Maria I ; Bindels, Laure B. ; Gomes-Neto, João Carlos ; Schmaltz, Robert J ; Segura Munoz, Rafael R ; Cody, Liz A ; Moxley, Rodney A ; Hostetter, Jesse ; Hutkins, Robert W ; Ramer-Tait, Amanda E. Galactooligosaccharide supplementation provides protection against Citrobacter rodentium-induced colitis without limiting pathogen burden.. In: Microbiology, Vol. 164, no. 2, p. 154-162 (2018). doi:10.1099/mic.0.000593.
2018
Delzenne, Nathalie M. ; Bindels, Laure B.. Gut microbiota in 2017: Contribution of gut microbiota-host cooperation to drug efficacy.. In: Nature Reviews. Gastroenterology & Hepatology, Vol. 15, no. 2, p. 69-70 (2018). doi:10.1038/nrgastro.2017.170.
2018
Pachikian, Barbara D. ; Druart, Céline ; Catry, Emilie ; Bindels, Laure B. ; Neyrinck, Audrey M. ; Larondelle, Yvan ; Cani, Patrice D. ; Delzenne, Nathalie M.. Implication of trans-11,trans-13 conjugated linoleic acid in the development of hepatic steatosis.. In: PLoS One, Vol. 13, no. 2, p. e0192447 [1-14] (2018). doi:10.1371/journal.pone.0192447.
2018
Gueugneau, Marine ; d'Hose, Donatienne ; Barbé, Caroline ; de Barsy, Marie ; Lause, Pascale ; Maiter, Dominique ; Bindels, Laure B. ; Delzenne, Nathalie M. ; Schaeffer, Laurent ; Gangloff, Yann-Gaël ; Chambon, Christophe ; Coudy-Gandilhon, Cécile ; Béchet, Daniel ; Thissen, Jean-Paul. Increased Serpina3n release into circulation during glucocorticoid-mediated muscle atrophy.. In: Journal of cachexia, sarcopenia and muscle, Vol. 9, no. 5, p. 929-946 (2018). doi:10.1002/jcsm.12315.
2018
Bindels, Laure B. ; Neyrinck, Audrey M. ; Loumaye, Audrey ; Catry, Emilie ; Walgrave, Hannah ; Cherbuy, Claire ; Leclercq, Sophie ; Van Hul, Matthias ; Plovier, Hubert ; Pachikian, Barbara D. ; Bermúdez-Humarán, Luis G ; Langella, Philippe ; Cani, Patrice D. ; Thissen, Jean-Paul ; Delzenne, Nathalie M.. Increased gut permeability in cancer cachexia: mechanisms and clinical relevance.. In: OncoTarget, Vol. 9, no.26, p. 18224-18238 (2018). doi:10.18632/oncotarget.24804.
2018
Hiel, Sophie ; Neyrinck, Audrey M. ; Rodriguez, Julie ; Pachikian, Barbara D. ; Bouzin, Caroline ; Thissen, Jean-Paul ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Inulin Improves Postprandial Hypertriglyceridemia by Modulating Gene Expression in the Small Intestine.. In: Nutrients, Vol. 10, no. 5, p. 532 [1-13] (2018). doi:10.3390/nu10050532.
2018
Pötgens, Sarah ; Brossel, Hélène ; Sboarina, Martina ; Catry, Emilie ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Delzenne, Nathalie M. ; Bindels, Laure B.. Klebsiella oxytoca expands in cancer cachexia and acts as a gut pathobiont contributing to intestinal dysfunction.. In: Scientific Reports, Vol. 8, no.1, p. 12321 [1-12] (2018). doi:10.1038/s41598-018-30569-5.
2018
Delzenne, Nathalie M. ; Bindels, Laure B.. Microbiome metabolomics reveals new drivers of human liver steatosis.. In: Nature Medicine, Vol. 24, no.7, p. 906-907 (2018). doi:10.1038/s41591-018-0126-3.
2018
Suriano, Francesco ; Neyrinck, Audrey M. ; Verspreet, Joran ; Olivares Sevilla, Marta ; Leclercq, Sophie ; Van de Wiele, Tom ; Courtin, Christophe M. ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Particle size determines the anti-inflammatory effect of wheat bran in a model of fructose over-consumption: Implication of the gut microbiota. In: Journal of Functional Foods, Vol. 41, p. 155-162 (2018). doi:10.1016/j.jff.2017.12.035.
2018
Pötgens, Sarah ; Sboarina, Martina ; Bindels, Laure B.. Polyunsaturated fatty acids, polyphenols, amino acids, prebiotics: can they help to tackle cancer cachexia and related inflammation?. In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 21, no. 6, p. 458-464 (2018). doi:10.1097/MCO.0000000000000505.
2018
Catry, Emilie ; Bindels, Laure B. ; Tailleux, Anne ; Lestavel, Sophie ; Neyrinck, Audrey M. ; Goossens, Jean-François ; Lobysheva, Irina ; Plovier, Hubert ; Essaghir, Ahmed ; Demoulin, Jean-Baptiste ; Bouzin, Caroline ; Pachikian, Barbara D. ; Cani, Patrice D. ; Staels, Bart ; Dessy, Chantal ; Delzenne, Nathalie M.. Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction.. In: Gut, Vol. 67, no.2, p. 271-283 (2018). doi:10.1136/gutjnl-2016-313316.
2018
Olivares Sevilla, Marta ; Neyrinck, Audrey M. ; Pötgens, Sarah ; Beaumont, Martin ; Salazar, Nuria ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. The DPP-4 inhibitor vildagliptin impacts the gut microbiota and prevents disruption of intestinal homeostasis induced by a Western diet in mice.. In: Diabetologia : clinical and experimental diabetes and metabolism, Vol. 61, no. 8, p. 1838-1848 (2018). doi:10.1007/s00125-018-4647-6.
2018
Olivares Sevilla, Marta ; Schüppel, Valentina ; Hassan, Ahmed M. ; Beaumont, Martin ; Neyrinck, Audrey M. ; Bindels, Laure B. ; Benítez-Páez, Alfonso ; Sanz, Yolanda ; Haller, Dirk ; Holzer, Peter ; Delzenne, Nathalie M.. The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host Health. In: Frontiers in Microbiology, Vol. 9, p. 1900 [1-10] (2018). doi:10.3389/fmicb.2018.01900.
2018
Beaumont, Martin ; Neyrinck, Audrey M. ; Olivares Sevilla, Marta ; Rodriguez, Julie ; de Rocca Serra, Audrey ; Roumain, Martin ; Bindels, Laure B. ; Cani, Patrice D. ; Evenepoel, Pieter ; Muccioli, Giulio ; Demoulin, Jean-Baptiste ; Delzenne, Nathalie M.. The gut microbiota metabolite indole alleviates liver inflammation in mice.. In: The FASEB Journal, Vol. 32, no. 12, p. fj201800544 [1-13] (2018). doi:10.1096/fj.201800544.
2018
Neyrinck, Audrey M. ; Hiel, Sophie ; Bouzin, Caroline ; Campayo, Vicenta Garcia ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Wheat-derived arabinoxylan oligosaccharides with bifidogenic properties abolishes metabolic disorders induced by western diet in mice.. In: Nutrition and Diabetes, Vol. 8, no.1, p. 15 [1-5] (2018). doi:10.1038/s41387-018-0019-z.
2017
Gomes-Neto, João Carlos ; Kittana, Hatem ; Mantz, Sara ; Segura Munoz, Rafael R ; Schmaltz, Robert J ; Bindels, Laure B. ; Clarke, Jennifer ; Hostetter, Jesse M ; Benson, Andrew K ; Walter, Jens ; Ramer-Tait, Amanda E. A gut pathobiont synergizes with the microbiota to instigate inflammatory disease marked by immunoreactivity against other symbionts but not itself.. In: Scientific Reports, Vol. 7, p. 17707 (2017). doi:10.1038/s41598-017-18014-5.
2017
Neyrinck, Audrey M. ; Bindels, Laure B. ; Geurts, Lucie ; Van Hul, Matthias ; Cani, Patrice D. ; Delzenne, Nathalie M.. A polyphenolic extract from green tea leaves activates fat browning in high-fat-diet-induced obese mice. In: The Journal of Nutritional Biochemistry, Vol. 49, p. 15-21 (2017). doi:10.1016/j.jnutbio.2017.07.008.
2017
Suriano, Francesco ; Bindels, Laure B. (co-first author) ; Verspreet, Joran ; Courtin, Christophe M. ; Verbeke, Kristin ; Cani, Patrice D. ; Neyrinck, Audrey M. ; Delzenne, Nathalie M.. Fat binding capacity and modulation of the gut microbiota both determine the effect of wheat bran fractions on adiposity. In: Scientific Reports, Vol. 7, no. 1, p. 5621 [1-13] (2017). doi:10.1038/s41598-017-05698-y.
2017
Bindels, Laure B. ; Porporato, Paolo ; Ducastel, Sarah ; Sboarina, Martina ; Neyrinck, Audrey M. ; Dewulf, Evelyne ; Feron, Olivier ; Lestavel, Sophie ; Cani, Patrice D. ; Staels, Bart ; Sonveaux, Pierre ; Delzenne, Nathalie M.. Ffar2 expression regulates leukaemic cell growth in vivo.. In: The British journal of cancer, Vol. 117, no. 9, p. 1336-1340 (2017). doi:10.1038/bjc.2017.307.
2017
Reid, Gregor ; Abrahamsson, Thomas Robert ; Bailey, Michael ; Bindels, Laure B. ; Bubnov, Rostyslav ; Ganguli, Kriston ; Martoni, Christopher ; O'Neill, Catherine ; Savignac, Hélène M ; Stanton, Catherine ; Ship, Noam ; Surette, Michael ; Tuohy, Kieran ; van Hemert, Saskia. How do probiotics and prebiotics function at distant sites?. In: Beneficial Microbes, Vol. 8, no.4, p. 521-533 (2017). doi:10.3920/BM2016.0222.
2017
Leclercq, Sophie ; Mian, Firoz M ; Stanisz, Andrew M ; Bindels, Laure B. ; Cambier, Emmanuel ; Ben-Amram, Hila ; Koren, Omry ; Forsythe, Paul ; Bienenstock, John. Low-dose penicillin in early life induces long-term changes in murine gut microbiota, brain cytokines and behavior. In: Nature Communications, Vol. 8, p. 15062 ^1-12] (2017). doi:10.1038/ncomms15062.
2017
Bindels, Laure B. ; Segura Munoz, Rafael R ; Gomes-Neto, João Carlos ; Mutemberezi, Valentin ; Martínez, Inés ; Salazar, Nuria ; Cody, Elizabeth A ; Quintero-Villegas, Maria I ; Kittana, Hatem ; de Los Reyes-Gavilán, Clara G ; Schmaltz, Robert J ; Muccioli, Giulio ; Walter, Jens ; Ramer-Tait, Amanda E. Resistant starch can improve insulin sensitivity independently of the gut microbiota. In: Microbiome, Vol. 5, no.1, p. 12 [1-16] (2017). doi:10.1186/s40168-017-0230-5.
2017
Neyrinck, Audrey M. ; Etxeberria, Usune ; Taminiau, Bernard ; Daube, Georges ; Van Hul, Matthias ; Everard, Amandine ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Rhubarb extract prevents hepatic inflammation induced by acute alcohol intake, an effect related to the modulation of the gut microbiota.. In: Molecular Nutrition & Food Research, Vol. 61, no. 1, p. 1500899 [1-12] (2017). doi:10.1002/mnfr.201500899.
2017
Neyrinck, Audrey M. ; Taminiau, Bernard ; Walgrave, Hannah ; Daube, Georges ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Spirulina Protects against Hepatic Inflammation in Aging: An Effect Related to the Modulation of the Gut Microbiota?. In: Nutrients, Vol. 9, no.6, p. 633 [1-13] (2017). doi:10.3390/nu9060633.
2016
Bindels, Laure B. ; Leclercq, Isabelle. Colonic acetate in obesity: location matters!. In: Clinical Science, Vol. 130, no.22, p. 2083-2086 (2016). doi:10.1042/CS20160556.
2016
Yang, Junyi ; Bindels, Laure B. ; Segura Munoz, Rafael R ; Martínez, Inés ; Walter, Jens ; Ramer-Tait, Amanda E ; Rose, Devin J. Disparate Metabolic Responses in Mice Fed a High-Fat Diet Supplemented with Maize-Derived Non-Digestible Feruloylated Oligo- and Polysaccharides Are Linked to Changes in the Gut Microbiota. In: PLoS One, Vol. 11, no.1, p. e0146144 (2016). doi:10.1371/journal.pone.0146144.
2016
Neyrinck, Audrey M. ; Pachikian, Barbara D. ; Taminiau , Bernard ; Daube , Georges ; Frédérick, Raphaël ; Cani, Patrice D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Intestinal Sucrase as a Novel Target Contributing to the Regulation of Glycemia by Prebiotics. In: PLoS One, Vol. 11, no.8, p. e0160488 [1-13] (2016). doi:10.1371/journal.pone.0160488.
2016
Bindels, Laure B. ; Thissen, Jean-Paul. Nutrition in cancer patients with cachexia: A role for the gut microbiota?. In: Clinical Nutrition Experimental, Vol. 6, no. 2016, p. 74-82 (2016). doi:10.1016/j.yclnex.2015.11.001.
2016
Hutkins, Robert W ; Krumbeck, Janina A ; Bindels, Laure B. ; Cani, Patrice D. ; Fahey, George ; Goh, Yong Jun ; Hamaker, Bruce ; Martens, Eric C ; Mills, David A ; Rastal, Robert A ; Vaughan, Elaine ; Sanders, Mary Ellen. Prebiotics: why definitions matter.. In: Current Opinion in Biotechnology, Vol. 37, p. 1-7 (2016). doi:10.1016/j.copbio.2015.09.001.
2016
Bindels, Laure B. ; Neyrinck, Audrey M. ; Claus, Sandrine P ; Le Roy, Caroline I ; Grangette, Corinne ; Pot, Bruno ; Martinez, Inés ; Walter, Jens ; Cani, Patrice D. ; Delzenne, Nathalie M.. Synbiotic approach restores intestinal homeostasis and prolongs survival in leukaemic mice with cachexia. In: The I S M E Journal : multidisciplinary journal of microbial ecology, Vol. 10, no. 6, p. 1456-70 (2016). doi:10.1038/ismej.2015.209.
2015
Druart, Céline ; Bindels, Laure B. (co-first author) ; Schmaltz, Robert ; Neyrinck, Audrey M. ; Cani, Patrice D. ; Walter, Jens ; Ramer-Tait, Amanda E ; Delzenne, Nathalie M.. Ability of the gut microbiota to produce PUFA-derived bacterial metabolites: Proof of concept in germ-free versus conventionalized mice.. In: Molecular Nutrition & Food Research, Vol. 59, no. 8, p. 1603–1613 (2015). doi:10.1002/mnfr.201500014.
2015
Delzenne, Nathalie M. ; Bindels, Laure B.. Gut microbiota: Ganoderma lucidum, a new prebiotic agent to treat obesity?. In: Nature Reviews. Gastroenterology & Hepatology, Vol. 12, no.10, p. 553-554 (2015). doi:10.1038/nrgastro.2015.137.
2015
Delzenne, Nathalie M. ; Cani, Patrice D. ; Everard, Amandine ; Neyrinck, Audrey M. ; Bindels, Laure B.. Gut microorganisms as promising targets for the management of type 2 diabetes.. In: Diabetologia : clinical and experimental diabetes and metabolism, Vol. 58, no.10, p. 2206-2217 (2015). doi:10.1007/s00125-015-3712-7.
2015
Simon, Marie-Christine ; Strassburger, Klaus ; Nowotny, Bettina ; Kolb, Hubert ; Nowotny, Peter ; Burkart, Volker ; Zivehe, Fariba ; Hwang, Jong-Hee ; Stehle, Peter ; Pacini, Giovanni ; Hartmann, Bolette ; Holst, Jens J ; MacKenzie, Colin ; Bindels, Laure B. ; Martinez, Ines ; Walter, Jens ; Henrich, Birgit ; Schloot, Nanette C ; Roden, Michael. Intake of Lactobacillus reuteri improves incretin and insulin secretion in glucose tolerant humans: a proof of concept. In: Diabetes Care, Vol. 38, no. 10, p. 1827-1834 (2015). doi:10.2337/dc14-2690.
2015
Salazar Garzo, Nuria ; Dewulf, Evelyne M. ; Neyrinck, Audrey M. ; Bindels, Laure B. ; Cani, Patrice D. ; Mahillon, Jacques ; de Vos, Willem M. ; Thissen, Jean-Paul ; Gueimonde, Miguel ; de los Reyes-Gavilan, Clara G. ; Delzenne, Nathalie M.. Inulin-type fructans modulate intestinal Bifidobacterium species populations and decrease fecal short-chain fatty acids in obese women. In: Clinical Nutrition, Vol. 34, no.3, p. 501–507 (2015). doi:10.1016/j.clnu.2014.06.001.
2015
Neyrinck, Audrey M. ; Catry, Emilie ; Sohet, Florence M. ; Cani, Patrice D. ; Pachikian, Barbara D. ; Bindels, Laure B. ; Delzenne, Nathalie M.. Lack of anti-inflammatory effect of coenzyme Q10 supplementation in the liver of rodents after lipopolysaccharide challenge. In: Clinical Nutrition Experimental, Vol. 1, p. 10-18 (2015). doi:10.1016/j.yclnex.2015.07.002.
2015
Bindels, Laure B. ; Neyrinck, Audrey M. (co-first author) ; Salazar Garzo, Nuria ; Taminiau, Bernard ; Druart, Céline ; Muccioli, Giulio ; François, Emmanuelle ; Blecker, Christophe ; Richel, Aurore ; Daube, Georges ; Mahillon, Jacques ; de Los Reyes-Gavilán, Clara G ; Cani, Patrice D. ; Delzenne, Nathalie M.. Non Digestible Oligosaccharides Modulate the Gut Microbiota to Control the Development of Leukemia and Associated Cachexia in Mice. In: PLoS One, Vol. 10, no. 6, p. e0131009 [1-16] (2015). doi:10.1371/journal.pone.0131009.
2015
Bindels, Laure B. ; Walter, Jens ; Ramer-Tait, Amanda E.. Resistant starches for the management of metabolic diseases. In: Current Opinion in Clinical Nutrition and Metabolic Care, Vol. 18, no.6, p. 559-565 (2015). doi:10.1097/MCO.0000000000000223.
2015
Bindels, Laure B. ; Delzenne, Nathalie M. ; Cani, Patrice D. ; Walter, Jens. Towards a more comprehensive concept for prebiotics. In: Nature Reviews. Gastroenterology & Hepatology, Vol. 12, no. 5, p. 303-310 (2015). doi:10.1038/nrgastro.2015.47.